Dopamine beta-monooxygenase

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In enzymology, a dopamine beta-monooxygenase (EC 1.14.17.1) is an enzyme that catalyzes the chemical reaction

3,4-dihydroxyphenethylamine + ascorbate + O₂ $\rightleftharpoons$ noradrenaline + dehydroascorbate + H₂O

The 3 substrates of this enzyme are 3,4-dihydroxyphenethylamine, ascorbate, and O₂, whereas its 3 products are noradrenaline, dehydroascorbate, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced ascorbate as one donor, and incorporation of one ato of oxygen into the other donor. The systematic name of this enzyme class is 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating). Other names in common use include dopamine beta-hydroxylase, MDBH (membrane-associated dopamine beta-monooxygenase), SDBH (soluble dopamine beta-monooxygenase), dopamine-B-hydroxylase, oxygenase, dopamine beta-mono-, 3,4-dihydroxyphenethylamine beta-oxidase, 4-(2-aminoethyl)pyrocatechol beta-oxidase, dopa beta-hydroxylase, dopamine beta-oxidase, dopamine hydroxylase, phenylamine beta-hydroxylase, and (3,4-dihydroxyphenethylamine)beta-mono-oxygenase. This enzyme participates in tyrosine metabolism. It has 3 cofactors: copper, PQQ, and Fumarate.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1ZHB.

[edit] References

IUBMB entry for 1.14.17.1
BRENDA references for 1.14.17.1 (Recommended.)
PubMed references for 1.14.17.1
PubMed Central references for 1.14.17.1
Google Scholar references for 1.14.17.1
Friedman S, Kaufman S (1965). "3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity". J. Biol. Chem. 240: 4763–73. PMID 5846992.
Levin EY, Levenberg B and Kaufman S (1960). "The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine". J. Biol. Chem. 235: 2080–2086.