Dopamine agonist

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A dopamine agonist is a compound that activates dopamine receptors, mimicking the effect of the neurotransmitter dopamine.

Contents 1 Uses 2 Examples 3 See also 4 References 5 External links

[edit] Uses

Some medical drugs act as dopamine agonists; they are typically used for treating Parkinson's disease and certain pituitary tumors (prolactinoma), and may be useful for restless legs syndrome (RLS). Both Requip (Ropinirole) and Mirapex (Pramipexole) are FDA approved for the treatment of RLS.

There is also an ongoing clinical trial to test the effectiveness of Requip (ropinirole), a dopamine agonist, in reversing the symptoms of SSRI induced sexual dysfunction. ^[1]

[edit] Examples

Examples of dopamine agonists include:

• Parlodel (bromocriptine)
• Dostinex (cabergoline)
• Permax (pergolide) - Removed from market March 29,2007.^[2]

• Mirapex (pramipexole)
• Requip (ropinirole)
• Apokyn (apomorphine)
• Neupro (rotigotine)

[edit] See also

• Agonist

[edit] References

1. ^ ClinicalTrials.gov NCT00334048 - "Treating Sexual Dysfunction From SSRI Medication: a Study Comparing Requip CR to Placebo"
2. ^ FDA Announces Voluntary Withdrawal of Pergolide Products

[edit] External links

• MeSH Dopamine+Agonists

v • d • e Anti-parkinson drugs: dopaminergic agents (N04B) Dopa and derivatives Droxidopa • Levodopa • Melevodopa • Etilevodopa Adamantane derivatives Amantadine Dopamine agonists A-412,997 • Apomorphine • Bromocriptine • Cabergoline • Dihydrexidine • Dihydroergocryptine mesylate • Fenoldopam • Lisuride • Pergolide • Piribedil • Pramipexole • Propylnorapomorphine • Quinpirole • Ropinirole • Rotigotine • SKF 38393 • SKF 82958 MAOIs Selegiline • Rasagiline COMT inhibitors Entacapone • Tolcapone Other Budipine

v • d • e Receptor agonists, antagonists, and reuptake inhibitors BA/M: 5-HT (serotonin) receptor Serotonin receptor agonist • Serotonin antagonist (5-HT3) • Serotonin uptake inhibitor (SSRI) BA/M: Dopamine receptor Dopamine agonist • Dopamine antagonist • Dopamine reuptake inhibitor BA/M: Adrenergic receptor Adrenergic agonist (Alpha, Beta2) • Adrenergic antagonist (Alpha, Beta) • Adrenergic uptake inhibitor BA/M: Histamine receptor Histamine agonist • Histamine antagonist (H1, H2) Acetylcholine receptor Cholinergic (Muscarinic, Nicotinic) • Anticholinergic (Muscarinic, Nicotinic) • Acetylcholinesterase inhibitor AA: GABA receptor GABA agonist • GABA antagonist AA: Glutamate receptor NMDA receptor (NMDA receptor antagonist)