Dolichyl-phosphate beta-glucosyltransferase

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In enzymology, a dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) is an enzyme that catalyzes the chemical reaction

UDP-glucose + dolichyl phosphate $\rightleftharpoons$ UDP + dolichyl beta-D-glucosyl phosphate

Thus, the two substrates of this enzyme are UDP-glucose and dolichyl phosphate, whereas its two products are UDP and dolichyl beta-D-glucosyl phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase. Other names in common use include polyprenyl phosphate:UDP-D-glucose glucosyltransferase, UDP-glucose dolichyl-phosphate glucosyltransferase, uridine diphosphoglucose-dolichol glucosyltransferase, UDP-glucose:dolichol phosphate glucosyltransferase, UDP-glucose:dolicholphosphoryl glucosyltransferase, UDP-glucose:dolichyl monophosphate glucosyltransferase, and UDP-glucose:dolichyl phosphate glucosyltransferase. This enzyme participates in n-glycan biosynthesis.

[edit] References

IUBMB entry for 2.4.1.117
BRENDA references for 2.4.1.117 (Recommended.)
PubMed references for 2.4.1.117
PubMed Central references for 2.4.1.117
Google Scholar references for 2.4.1.117
Behrens NH, Leloir LF (1970). "Dolichol monophosphate glucose: an intermediate in glucose transfer in liver". Proc. Natl. Acad. Sci. U. S. A. 66: 153–9. PMID 5273893.
Herscovics A, Bugge B, Jeanloz RW (1977). "Glucosyltransferase activity in calf pancreas microsomes. Formation of dolichyl D[14C]glucosyl phosphate and 14C-labeled lipid-linked oligosaccharides from UDP-D-[14C]glucose". J. Biol. Chem. 252: 2271–7. PMID 849929.
Villemez CL, Carlo PL (1979). "Properties of a soluble polyprenyl phosphate: UDP-D-glucose glucosyltransferase". J. Biol. Chem. 254: 4814–9. PMID 438216.