Dolichyl-phosphate beta-D-mannosyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) is an enzyme that catalyzes the chemical reaction

GDP-mannose + dolichyl phosphate $\rightleftharpoons$ GDP + dolichyl D-mannosyl phosphate

Thus, the two substrates of this enzyme are GDP-mannose and dolichyl phosphate, whereas its two products are GDP and dolichyl D-mannosyl phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase. Other names in common use include GDP-Man:DolP mannosyltransferase, dolichyl mannosyl phosphate synthase, dolichyl-phospho-mannose synthase, GDP-mannose:dolichyl-phosphate mannosyltransferase, guanosine diphosphomannose-dolichol phosphate mannosyltransferase, dolichol phosphate mannose synthase, dolichyl phosphate mannosyltransferase, dolichyl-phosphate mannose synthase, GDP-mannose-dolichol phosphate mannosyltransferase, GDP-mannose-dolichylmonophosphate mannosyltransferase, mannosylphosphodolichol synthase, and mannosylphosphoryldolichol synthase. This enzyme participates in n-glycan biosynthesis.

[edit] References

IUBMB entry for 2.4.1.83
BRENDA references for 2.4.1.83 (Recommended.)
PubMed references for 2.4.1.83
PubMed Central references for 2.4.1.83
Google Scholar references for 2.4.1.83
Babczinski P, Haselbeck A, Tanner W (1980). "Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme". Eur. J. Biochem. 105: 509–15. doi:10.1111/j.1432-1033.1980.tb04526.x. PMID 6989607.
Bretthauer RK, Wu S, Irwin WE (1973). "Enzymatic transfer of mannose from guanosine diphosphate mannose to dolichol phosphate in yeast (Hansenula holstii). A possible step in mannan synthesis". Biochim. Biophys. Acta. 304: 736–47. PMID 4726855.
Haselbeck A (1989). "Purification of GDP mannose:dolichyl-phosphate O-beta-D-mannosyltransferase from Saccharomyces cerevisiae". Eur. J. Biochem. 181: 663–8. doi:10.1111/j.1432-1033.1989.tb14774.x. PMID 2659345.
Palamarczyk G, Lehle L, Mankowski T, Chojnacki T, Tanner W (1980). "Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives". Eur. J. Biochem. 105: 517–23. doi:10.1111/j.1432-1033.1980.tb04527.x. PMID 6445267.
Richards JB, Hemming FW (1972). "The transfer of mannose from guanosine diphosphate mannose to dolichol phosphate and protein by pig liver endoplasmic reticulum". Biochem. J. 130: 77–93. PMID 4655455.