Dolichyl-phosphate-mannose-protein mannosyltransferase

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In enzymology, a dolichyl-phosphate-mannose-protein mannosyltransferase (EC 2.4.1.109) is an enzyme that catalyzes the chemical reaction

dolichyl phosphate D-mannose + protein $\rightleftharpoons$ dolichyl phosphate + O-D-mannosylprotein

Thus, the two substrates of this enzyme are dolichyl phosphate D-mannose and protein, whereas its two products are dolichyl phosphate and O-D-mannosylprotein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase. Other names in common use include dolichol phosphomannose-protein mannosyltransferase, and protein O-D-mannosyltransferase. A human gene that codes for this enzyme is POMT1.

[edit] References

IUBMB entry for 2.4.1.109
BRENDA references for 2.4.1.109 (Recommended.)
PubMed references for 2.4.1.109
PubMed Central references for 2.4.1.109
Google Scholar references for 2.4.1.109
Babczinski P, Haselbeck A, Tanner W (1980). "Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme". Eur. J. Biochem. 105: 509–15. PMID 6989607.
Palamarczyk G, Lehle L, Mankowski T, Chojnacki T, Tanner W (1980). "Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives". Eur. J. Biochem. 105: 517–23. PMID 6445267.