Dolichol kinase

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In enzymology, a dolichol kinase (EC 2.7.1.108) is an enzyme that catalyzes the chemical reaction

CTP + dolichol CDP + dolichyl phosphate

Thus, the two substrates of this enzyme are CTP and dolichol, whereas its two products are CDP and dolichyl phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is CTP:dolichol O-phosphotransferase. This enzyme is also called dolichol phosphokinase. This enzyme participates in n-glycan biosynthesis.

[edit] References

• IUBMB entry for 2.7.1.108
• BRENDA references for 2.7.1.108 (Recommended.)
• PubMed references for 2.7.1.108
• PubMed Central references for 2.7.1.108
• Google Scholar references for 2.7.1.108
• Burton WA, Scher MG, Waechter CJ (1979). "Enzymatic phosphorylation of dolichol in central nervous tissue". J. Biol. Chem. 254: 7129–36. PMID 457672. 
• Rip JW, Carroll KK (1980). "Properties of a dolichol phosphokinase activity associated with rat liver microsomes". Can. J. Biochem. 58: 1051–6. PMID 6257336. 

[edit] External links

The CAS registry number for this enzyme class is 71768-07-5.

• IUBMB entry for 2.7.1.108

• KEGG entry for 2.7.1.108

• BRENDA entry for 2.7.1.108

• NiceZyme view of 2.7.1.108

• EC2PDB: PDB structures for 2.7.1.108

• PRIAM entry for 2.7.1.108

• PUMA2 entry for 2.7.1.108

• IntEnz: Integrated Enzyme entry for 2.7.1.108

• MetaCyc entry for 2.7.1.108

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004168: dolichol kinase

• AMIGO entry for GO code 0004168: dolichol kinase