DOLK

From Wikipedia, the free encyclopedia

Dolichol kinase

Identifiers

DOLK; DK1; KIAA1094; TMEM15

External IDs

OMIM: 610746 MGI: 2677836 HomoloGene: 8940

Gene ontology
Molecular Function:	• phosphatidate cytidylyltransferase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• phospholipid biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_014908 (mRNA)
NP_055723 (protein)

NM_177648 (mRNA)
NP_808316 (protein)

Location

Chr 9: 130.75 - 130.75 Mb

Chr 2: 30.11 - 30.11 Mb

Pubmed search

[1]

[2]

Dolichol kinase, also known as DOLK, is a human gene.^[1]

[edit] References

^ Entrez Gene: DOLK dolichol kinase.

[edit] Further reading

Kranz C, Jungeblut C, Denecke J, et al. (2007). "A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy.". Am. J. Hum. Genet. 80 (3): 433–40. doi:10.1086/512130. PMID 17273964.
Shridas P, Waechter CJ (2006). "Human dolichol kinase, a polytopic endoplasmic reticulum membrane protein with a cytoplasmically oriented CTP-binding site.". J. Biol. Chem. 281 (42): 31696–704. doi:10.1074/jbc.M604087200. PMID 16923818.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fernandez F, Shridas P, Jiang S, et al. (2003). "Expression and characterization of a human cDNA that complements the temperature-sensitive defect in dolichol kinase activity in the yeast sec59-1 mutant: the enzymatic phosphorylation of dolichol and diacylglycerol are catalyzed by separate CTP-mediated kinase activities in Saccharomyces cerevisiae.". Glycobiology 12 (9): 555–62. PMID 12213788.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. PMID 10470851.