DOK4

From Wikipedia, the free encyclopedia

Docking protein 4

Identifiers

DOK4; FLJ10488

External IDs

OMIM: 608333 MGI: 2148865 HomoloGene: 10009

Gene ontology
Molecular Function:	• transmembrane receptor protein tyrosine kinase signaling protein activity • insulin receptor binding
Biological Process:	• MAPKKK cascade • transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018110 (mRNA)
NP_060580 (protein)

NM_053246 (mRNA)
NP_444476 (protein)

Location

Chr 16: 56.06 - 56.08 Mb

Chr 8: 97.75 - 97.77 Mb

Pubmed search

[1]

[2]

Docking protein 4, also known as DOK4, is a human gene.^[1]

[edit] References

^ Entrez Gene: DOK4 docking protein 4.

[edit] Further reading

Al-Sarraf N, Reiff JN, Hinrichsen J, et al. (2007). "DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma.". Int. J. Cancer 121 (5): 992-8. doi:10.1002/ijc.22776. PMID 17443497.
Uchida M, Enomoto A, Fukuda T, et al. (2007). "Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase.". J. Cell. Sci. 119 (Pt 15): 3067-77. doi:10.1242/jcs.03043. PMID 16820412.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Cai D, Dhe-Paganon S, Melendez PA, et al. (2003). "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.". J. Biol. Chem. 278 (28): 25323-30. doi:10.1074/jbc.M212430200. PMID 12730241.
Favre C, Gérard A, Clauzier E, et al. (2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells.". Genes Immun. 4 (1): 40-5. doi:10.1038/sj.gene.6363891. PMID 12595900.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Grimm J, Sachs M, Britsch S, et al. (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.". J. Cell Biol. 154 (2): 345-54. PMID 11470823.
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295-308. doi:10.1006/geno.1999.5927. PMID 10493829.