DOK3

From Wikipedia, the free encyclopedia

Docking protein 3

Identifiers

DOK3; FLJ22570; FLJ39939

External IDs

Gene ontology
Molecular Function:	• insulin receptor binding • protein binding
Cellular Component:	• cytoplasm
Biological Process:	• Ras protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_024872 (mRNA)
NP_079148 (protein)

XM_984466 (mRNA)
XP_989560 (protein)

Location

Chr 5: 176.86 - 176.87 Mb

Chr 13: 55.53 - 55.54 Mb

Pubmed search

[1]

[2]

Docking protein 3, also known as DOK3, is a human gene.^[1]

[edit] References

^ Entrez Gene: DOK3 docking protein 3.

[edit] Further reading

Cong F, Yuan B, Goff SP (2000). "Characterization of a novel member of the DOK family that binds and modulates Abl signaling.". Mol. Cell. Biol. 19 (12): 8314-25. PMID 10567556.
Lemay S, Davidson D, Latour S, Veillette A (2000). "Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling.". Mol. Cell. Biol. 20 (8): 2743-54. PMID 10733577.
Grimm J, Sachs M, Britsch S, et al. (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.". J. Cell Biol. 154 (2): 345-54. PMID 11470823.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Favre C, Gérard A, Clauzier E, et al. (2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells.". Genes Immun. 4 (1): 40-5. doi:10.1038/sj.gene.6363891. PMID 12595900.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Robson JD, Davidson D, Veillette A (2004). "Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3.". Mol. Cell. Biol. 24 (6): 2332-43. PMID 14993273.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Honma M, Higuchi O, Shirakata M, et al. (2007). "Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.". Genes Cells 11 (2): 143-51. doi:10.1111/j.1365-2443.2006.00926.x. PMID 16436051.