DOCK9

From Wikipedia, the free encyclopedia

Dedicator of cytokinesis 9

PDB rendering based on 1wg7.

Available structures: 1wg7

Identifiers

DOCK9; DKFZp686C11110; DKFZp686D2047; DKFZp686N04132; FLJ16744; FLJ44528; FLJ45282; FLJ45601; KIAA1058; KIAA1085; ZIZ1; zizimin1

External IDs

OMIM: 607325 MGI: 106321 HomoloGene: 41026

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • GTP binding • Rho GTPase binding • GTPase binding
Cellular Component:	• cellular_component
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015296 (mRNA)
NP_056111 (protein)

XM_001004695 (mRNA)
XP_001004695 (protein)

Location

Chr 13: 98.24 - 98.54 Mb

Chr 14: 120.68 - 120.87 Mb

Pubmed search

[1]

[2]

Dedicator of cytokinesis 9, also known as DOCK9, is a human gene.^[1]

[edit] References

^ Entrez Gene: DOCK9 dedicator of cytokinesis 9.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Kwofie MA, Skowronski J (2008). "Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors.". J. Biol. Chem. 283 (6): 3088-96. doi:10.1074/jbc.M705170200. PMID 18056264.
Meller N, Westbrook MJ, Shannon JD, et al. (2008). "Function of the N-terminus of zizimin1: autoinhibition and membrane targeting.". Biochem. J. 409 (2): 525-33. doi:10.1042/BJ20071263. PMID 17935486.
Detera-Wadleigh SD, Liu CY, Maheshwari M, et al. (2007). "Sequence variation in DOCK9 and heterogeneity in bipolar disorder.". Psychiatr. Genet. 17 (5): 274-86. doi:10.1097/YPG.0b013e328133f352. PMID 17728666.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Côté JF, Vuori K (2003). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.". J. Cell. Sci. 115 (Pt 24): 4901-13. PMID 12432077.
Meller N, Irani-Tehrani M, Kiosses WB, et al. (2002). "Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.". Nat. Cell Biol. 4 (9): 639-47. doi:10.1038/ncb835. PMID 12172552.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197-205. PMID 10470851.