DOCK4

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Dedicator of cytokinesis 4
Identifiers
Symbol(s) DOCK4; FLJ34238; KIAA0716; MGC134911; MGC134912
External IDs OMIM: 607679 MGI: 1918006 HomoloGene: 56680
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9732 238130
Ensembl ENSG00000128512 ENSMUSG00000035954
Uniprot Q8N1I0 Q3US86
Refseq NM_014705 (mRNA)
NP_055520 (protein)		 NM_172803 (mRNA)
NP_766391 (protein)
Location Chr 7: 111.16 - 111.43 Mb Chr 12: 40.96 - 41.36 Mb
Pubmed search [1] [2]

Dedicator of cytokinesis 4, also known as DOCK4, is a human gene.[1]

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized.[1]

[edit] References

  1. ^ a b Entrez Gene: DOCK4 dedicator of cytokinesis 4.

[edit] Further reading

  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452. 
  • Côté JF, Vuori K (2003). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.". J. Cell. Sci. 115 (Pt 24): 4901–13. PMID 12432077. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yajnik V, Paulding C, Sordella R, et al. (2003). "DOCK4, a GTPase activator, is disrupted during tumorigenesis.". Cell 112 (5): 673–84. PMID 12628187. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Liang H, Castro PD, Ma J, Nagarajan L (2005). "Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms.". Cancer Genet. Cytogenet. 162 (2): 151–9. doi:10.1016/j.cancergencyto.2005.03.019. PMID 16213364. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Yan D, Li F, Hall ML, et al. (2006). "An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C).". J. Mol. Biol. 357 (3): 755–64. doi:10.1016/j.jmb.2006.01.017. PMID 16464467. 
  • Hiramoto K, Negishi M, Katoh H (2007). "Dock4 is regulated by RhoG and promotes Rac-dependent cell migration.". Exp. Cell Res. 312 (20): 4205–16. doi:10.1016/j.yexcr.2006.09.006. PMID 17027967. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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