DOCK2

From Wikipedia, the free encyclopedia

Dedicator of cytokinesis 2

Identifiers

DOCK2; FLJ46592; KIAA0209

External IDs

OMIM: 603122 MGI: 2149010 HomoloGene: 37984

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • protein binding • Rac GTPase activator activity • Rac guanyl-nucleotide exchange factor activity • T cell receptor binding
Cellular Component:	• cytoskeleton • membrane
Biological Process:	• lipid raft polarization • establishment of T cell polarity • formation of immunological synapse • chemotaxis • cytoskeleton organization and biogenesis • actin cytoskeleton organization and biogenesis • positive thymic T cell selection • negative thymic T cell selection • alpha-beta T cell proliferation • lymphocyte chemotaxis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004946 (mRNA)
NP_004937 (protein)

NM_033374 (mRNA)
NP_203538 (protein)

Location

Chr 5: 169 - 169.44 Mb

Chr 11: 34.13 - 34.63 Mb

Pubmed search

[1]

[2]

Dedicator of cytokinesis 2, also known as DOCK2, is a human gene.^[1]

The DOCK2 gene encodes a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: DOCK2 dedicator of cytokinesis 2.

[edit] Further reading

Reif K, Cyster J (2003). "The CDM protein DOCK2 in lymphocyte migration.". Trends Cell Biol. 12 (8): 368–73. PMID 12191913.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. PMID 9039502.
Nishihara H, Kobayashi S, Hashimoto Y, et al. (1999). "Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins.". Biochim. Biophys. Acta 1452 (2): 179–87. PMID 10559471.
Fukui Y, Hashimoto O, Sanui T, et al. (2001). "Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration.". Nature 412 (6849): 826–31. doi:10.1038/35090591. PMID 11518968.
Brugnera E, Haney L, Grimsley C, et al. (2002). "Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.". Nat. Cell Biol. 4 (8): 574–82. doi:10.1038/ncb824. PMID 12134158.
Nishihara H, Maeda M, Tsuda M, et al. (2002). "DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription.". Biochem. Biophys. Res. Commun. 296 (3): 716–20. PMID 12176041.
Nishihara H, Maeda M, Oda A, et al. (2003). "DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines.". Blood 100 (12): 3968–74. doi:10.1182/blood-2001-11-0032. PMID 12393632.
Côté JF, Vuori K (2003). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.". J. Cell. Sci. 115 (Pt 24): 4901–13. PMID 12432077.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sanui T, Inayoshi A, Noda M, et al. (2003). "DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1.". Blood 102 (8): 2948–50. doi:10.1182/blood-2003-01-0173. PMID 12829596.
Janardhan A, Swigut T, Hill B, et al. (2006). "HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis.". PLoS Biol. 2 (1): E6. doi:10.1371/journal.pbio.0020006. PMID 14737186.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Lu M, Kinchen JM, Rossman KL, et al. (2005). "A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.". Curr. Biol. 15 (4): 371–7. doi:10.1016/j.cub.2005.01.050. PMID 15723800.
García-Bernal D, Sotillo-Mallo E, Nombela-Arrieta C, et al. (2007). "DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin alpha4beta1.". J. Immunol. 177 (8): 5215–25. PMID 17015707.