DOC2B

From Wikipedia, the free encyclopedia

Double C2-like domains, beta

Identifiers

External IDs

OMIM: 604568 MGI: 1100497 HomoloGene: 20796

Gene ontology
Molecular Function:	• transporter activity • calcium ion binding • calcium-dependent phospholipid binding
Cellular Component:	• synaptic vesicle • membrane
Biological Process:	• transport

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003585 (mRNA)
NP_003576 (protein)

NM_007873 (mRNA)
NP_031899 (protein)

Location

n/a

Chr 11: 75.59 - 75.61 Mb

Pubmed search

[1]

[2]

Double C2-like domains, beta, also known as DOC2B, is a human gene.^[1]

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells.^[1]

[edit] References

^ ^a ^b Entrez Gene: DOC2B double C2-like domains, beta.

[edit] Further reading

Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.". Am. J. Hum. Genet. 72 (4): 918-30. PMID 12621583.
Duncan RR, Betz A, Shipston MJ, et al. (1999). "Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo.". J. Biol. Chem. 274 (39): 27347-50. PMID 10488064.
Nagano F, Orita S, Sasaki T, et al. (1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport.". J. Biol. Chem. 273 (46): 30065-8. PMID 9804756.
Orita S, Naito A, Sakaguchi G, et al. (1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery.". J. Biol. Chem. 272 (26): 16081-4. PMID 9195900.
Verhage M, de Vries KJ, Røshol H, et al. (1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion.". Neuron 18 (3): 453-61. PMID 9115738.
Kojima T, Fukuda M, Aruga J, Mikoshiba K (1997). "Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta).". J. Biochem. 120 (3): 671-6. PMID 8902635.
Sakaguchi G, Orita S, Maeda M, et al. (1996). "Molecular cloning of an isoform of Doc2 having two C2-like domains.". Biochem. Biophys. Res. Commun. 217 (3): 1053-61. PMID 8554557.
Orita S, Sasaki T, Naito A, et al. (1995). "Doc2: a novel brain protein having two repeated C2-like domains.". Biochem. Biophys. Res. Commun. 206 (2): 439-48. doi:10.1006/bbrc.1995.1062. PMID 7826360.