DOC2A

From Wikipedia, the free encyclopedia

Double C2-like domains, alpha

Identifiers

External IDs

OMIM: 604567 MGI: 109446 HomoloGene: 2657

Gene ontology
Molecular Function:	• transporter activity • binding • calcium ion binding • calcium-dependent phospholipid binding
Cellular Component:	• synaptic vesicle • membrane • synaptosome • synapse
Biological Process:	• transport • exocytosis • synaptic transmission • nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003586 (mRNA)
NP_003577 (protein)

NM_010069 (mRNA)
NP_034199 (protein)

Location

Chr 16: 29.92 - 29.93 Mb

Chr 7: 126.64 - 126.64 Mb

Pubmed search

[1]

[2]

Double C2-like domains, alpha, also known as DOC2A, is a human gene.^[1]

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.^[1]

[edit] References

^ ^a ^b Entrez Gene: DOC2A double C2-like domains, alpha.

[edit] Further reading

Orita S, Sasaki T, Naito A, et al. (1995). "Doc2: a novel brain protein having two repeated C2-like domains.". Biochem. Biophys. Res. Commun. 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360.
Sakaguchi G, Orita S, Maeda M, et al. (1996). "Molecular cloning of an isoform of Doc2 having two C2-like domains.". Biochem. Biophys. Res. Commun. 217 (3): 1053–61. PMID 8554557.
Verhage M, de Vries KJ, Røshol H, et al. (1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion.". Neuron 18 (3): 453–61. PMID 9115738.
Orita S, Naito A, Sakaguchi G, et al. (1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery.". J. Biol. Chem. 272 (26): 16081–4. PMID 9195900.
Mochida S, Orita S, Sakaguchi G, et al. (1998). "Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11418–22. PMID 9736751.
Nagano F, Orita S, Sasaki T, et al. (1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport.". J. Biol. Chem. 273 (46): 30065–8. PMID 9804756.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.