DNMT1

From Wikipedia, the free encyclopedia

DNA (cytosine-5-)-methyltransferase 1

Identifiers

DNMT1; CXXC9; DNMT; FLJ16293; MCMT; MGC104992

External IDs

OMIM: 126375 MGI: 94912 HomoloGene: 1055

Gene ontology
Molecular Function:	• DNA binding • DNA (cytosine-5-)-methyltransferase activity • transcription factor binding • methyltransferase activity • zinc ion binding • transferase activity • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • DNA methylation • transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001379 (mRNA)
NP_001370 (protein)

NM_010066 (mRNA)
NP_034196 (protein)

Location

Chr 19: 10.11 - 10.17 Mb

Chr 9: 20.66 - 20.7 Mb

Pubmed search

[1]

[2]

DNA (cytosine-5-)-methyltransferase 1, also known as DNMT1, is a human gene.

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities.^[1]

[edit] See also

DNA methyltransferase

[edit] References

^ Entrez Gene: DNMT1 DNA (cytosine-5-)-methyltransferase 1.

[edit] Further reading

Yen RW, Vertino PM, Nelkin BD, et al. (1992). "Isolation and characterization of the cDNA encoding human DNA methyltransferase.". Nucleic Acids Res. 20 (9): 2287–91. PMID 1594447.
Bestor T, Laudano A, Mattaliano R, Ingram V (1989). "Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases.". J. Mol. Biol. 203 (4): 971–83. PMID 3210246.
Hijmans EM, Voorhoeve PM, Beijersbergen RL, et al. (1995). "E2F-5, a new E2F family member that interacts with p130 in vivo.". Mol. Cell. Biol. 15 (6): 3082–9. PMID 7760804.
Yoder JA, Yen RW, Vertino PM, et al. (1997). "New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase.". J. Biol. Chem. 271 (49): 31092–7. PMID 8940105.
Chuang LS, Ian HI, Koh TW, et al. (1997). "Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1.". Science 277 (5334): 1996–2000. PMID 9302295.
Baylin SB (1997). "Tying it all together: epigenetics, genetics, cell cycle, and cancer.". Science 277 (5334): 1948–9. PMID 9333948.
Robertson KD, Uzvolgyi E, Liang G, et al. (1999). "The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.". Nucleic Acids Res. 27 (11): 2291–8. PMID 10325416.
Michaelson JS, Bader D, Kuo F, et al. (1999). "Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development.". Genes Dev. 13 (15): 1918–23. PMID 10444590.
Hsu DW, Lin MJ, Lee TL, et al. (1999). "Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues.". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9751–6. PMID 10449766.
Fuks F, Burgers WA, Brehm A, et al. (2000). "DNA methyltransferase Dnmt1 associates with histone deacetylase activity.". Nat. Genet. 24 (1): 88–91. doi:10.1038/71750. PMID 10615135.
Bonfils C, Beaulieu N, Chan E, et al. (2000). "Characterization of the human DNA methyltransferase splice variant Dnmt1b.". J. Biol. Chem. 275 (15): 10754–60. PMID 10753866.
Rountree MR, Bachman KE, Baylin SB (2000). "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.". Nat. Genet. 25 (3): 269–77. doi:10.1038/77023. PMID 10888872.
Robertson KD, Ait-Si-Ali S, Yokochi T, et al. (2000). "DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.". Nat. Genet. 25 (3): 338–42. doi:10.1038/77124. PMID 10888886.
Tatematsu KI, Yamazaki T, Ishikawa F (2000). "MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase.". Genes Cells 5 (8): 677–88. PMID 10947852.
Mizuno S, Chijiwa T, Okamura T, et al. (2001). "Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia.". Blood 97 (5): 1172–9. PMID 11222358.
Fatemi M, Hermann A, Pradhan S, Jeltsch A (2001). "The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA.". J. Mol. Biol. 309 (5): 1189–99. doi:10.1006/jmbi.2001.4709. PMID 11399088.
Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
Di Croce L, Raker VA, Corsaro M, et al. (2002). "Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor.". Science 295 (5557): 1079–82. doi:10.1126/science.1065173. PMID 11834837.
Pradhan S, Kim GD (2002). "The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity.". EMBO J. 21 (4): 779–88. doi:10.1093/emboj/21.4.779. PMID 11847125.
Rhee I, Bachman KE, Park BH, et al. (2002). "DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.". Nature 416 (6880): 552–6. doi:10.1038/416552a. PMID 11932749.