DNM2

From Wikipedia, the free encyclopedia

Dynamin 2

Identifiers

DNM2; CMTDI1; CMTDIB; DYN2; DYNII

External IDs

OMIM: 602378 MGI: 109547 HomoloGene: 68424

Gene ontology
Molecular Function:	• nucleotide binding • motor activity • GTPase activity • GTP binding • microtubule binding • transcription activator activity • hydrolase activity • enzyme binding
Cellular Component:	• cytoplasm • microtubule • postsynaptic membrane
Biological Process:	• G2/M transition of mitotic cell cycle • endocytosis • signal transduction • positive regulation of apoptosis • regulation of transcription • synaptic vesicle transport

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001005360 (mRNA)
NP_001005360 (protein)

NM_001039520 (mRNA)
NP_001034609 (protein)

Location

n/a

Chr 9: 21.18 - 21.26 Mb

Pubmed search

[1]

[2]

Dynamin 2, also known as DNM2, is a human gene.

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Four alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.^[1]

[edit] References

^ Entrez Gene: DNM2 dynamin 2.

[edit] Further reading

Sever S (2003). "Dynamin and endocytosis.". Curr. Opin. Cell Biol. 14 (4): 463–7. PMID 12383797.
Wiejak J, Wyroba E (2003). "Dynamin: characteristics, mechanism of action and function.". Cell. Mol. Biol. Lett. 7 (4): 1073–80. PMID 12511974.
Orth JD, McNiven MA (2003). "Dynamin at the actin-membrane interface.". Curr. Opin. Cell Biol. 15 (1): 31–9. PMID 12517701.
Diatloff-Zito C, Gordon AJ, Duchaud E, Merlin G (1995). "Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family.". Gene 163 (2): 301–6. PMID 7590285.
Klocke R, Augustin A, Ronsiek M, et al. (1997). "Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively.". Genomics 41 (2): 290–2. doi:10.1006/geno.1997.4634. PMID 9143510.
Kasai K, Shin HW, Shinotsuka C, et al. (1999). "Dynamin II is involved in endocytosis but not in the formation of transport vesicles from the trans-Golgi network.". J. Biochem. 125 (4): 780–9. PMID 10101292.
Vila-Coro AJ, Mellado M, Martín de Ana A, et al. (1999). "Characterization of RANTES- and aminooxypentane-RANTES-triggered desensitization signals reveals differences in recruitment of the G protein-coupled receptor complex.". J. Immunol. 163 (6): 3037–44. PMID 10477567.
Fish KN, Schmid SL, Damke H (2000). "Evidence that dynamin-2 functions as a signal-transducing GTPase.". J. Cell Biol. 150 (1): 145–54. PMID 10893263.
Salcini AE, Hilliard MA, Croce A, et al. (2001). "The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling.". Nat. Cell Biol. 3 (8): 755–60. doi:10.1038/35087075. PMID 11483962.
Wan KF, Sambi BS, Frame M, et al. (2001). "The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells.". J. Biol. Chem. 276 (41): 37802–8. doi:10.1074/jbc.M105087200. PMID 11502744.
Kennerson ML, Zhu D, Gardner RJ, et al. (2001). "Dominant intermediate Charcot-Marie-Tooth neuropathy maps to chromosome 19p12-p13.2.". Am. J. Hum. Genet. 69 (4): 883–8. PMID 11533912.
Okamoto PM, Gamby C, Wells D, et al. (2002). "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton.". J. Biol. Chem. 276 (51): 48458–65. doi:10.1074/jbc.M104927200. PMID 11583995.
Lee E, De Camilli P (2002). "Dynamin at actin tails.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 161–6. doi:10.1073/pnas.012607799. PMID 11782545.
Scott MP, Zappacosta F, Kim EY, et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
Schafer DA, Weed SA, Binns D, et al. (2003). "Dynamin2 and cortactin regulate actin assembly and filament organization.". Curr. Biol. 12 (21): 1852–7. PMID 12419186.
Modregger J, Schmidt AA, Ritter B, et al. (2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1.". J. Biol. Chem. 278 (6): 4160–7. doi:10.1074/jbc.M208568200. PMID 12456676.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Speer MC, Graham FL, Bonner E, et al. (2003). "Reduction in the minimum candidate interval in the dominant-intermediate form of Charcot-Marie-Tooth neuropathy to D19S586 to D19S432.". Neurogenetics 4 (2): 83–5. PMID 12481986.