DNA polymerase beta

From Wikipedia, the free encyclopedia

Polymerase (DNA directed), beta

PDB rendering based on 1bno.

Available structures: 1bno, 1bnp, 1bpb, 1bpd, 1bpe, 1bpx, 1bpy, 1bpz, 1dk2, 1dk3, 1huo, 1huz, 1jn3, 1mq2, 1mq3, 1nom, 1rpl, 1tv9, 1tva, 1zjm, 1zjn, 1zqa, 1zqb, 1zqc, 1zqd, 1zqe, 1zqf, 1zqg, 1zqh, 1zqi, 1zqj, 1zqk, 1zql, 1zqm, 1zqn, 1zqo, 1zqp, 1zqq, 1zqr, 1zqs, 1zqt, 1zqu, 1zqv, 1zqw, 1zqx, 1zqy, 1zqz, 2bpc, 2bpf, 2bpg, 2fmp, 2fmq, 2fms, 2i9g, 2iso, 2isp, 2p66, 7ice, 7icf, 7icg, 7ich, 7ici, 7icj, 7ick, 7icl, 7icm, 7icn, 7ico, 7icp, 7icq, 7icr, 7ics, 7ict, 7icu, 7icv, 8ica, 8icb, 8icc, 8ice, 8icf, 8icg, 8ich, 8ici, 8icj, 8ick, 8icl, 8icm, 8icn, 8ico, 8icp, 8icq, 8icr, 8ics, 8ict, 8icu, 8icv, 8icw, 8icx, 8icy, 8icz, 9ica, 9icb, 9icc, 9ice, 9icf, 9icg, 9ich, 9ici, 9icj, 9ick, 9icl, 9icm, 9icn, 9ico, 9icp, 9icq, 9icr, 9ics, 9ict, 9icu, 9icv, 9icw, 9icx, 9icy

Identifiers

Symbol(s)

POLB; MGC125976

External IDs

OMIM: 174760 MGI: 97740 HomoloGene: 2013

Gene ontology
Molecular Function:	• magnesium ion binding • beta DNA polymerase activity • microtubule binding • transferase activity • lyase activity • sodium ion binding • sequence-specific DNA binding
Cellular Component:	• intracellular • nucleus • cytoplasm • spindle microtubule
Biological Process:	• DNA-dependent DNA replication • DNA repair • anti-apoptosis • cell death

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002690 (mRNA)
NP_002681 (protein)

NM_011130 (mRNA)
NP_035260 (protein)

Location

Chr 8: 42.32 - 42.35 Mb

Chr 8: 24.09 - 24.12 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed), beta, also known as POLB, is a human gene.^[1]

In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. Also see POLA (MIM 312040).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: POLB polymerase (DNA directed), beta.

[edit] Further reading

Date T, Tanihara K, Yamamoto S, et al. (1992). "Two regions in human DNA polymerase beta mRNA suppress translation in Escherichia coli.". Nucleic Acids Res. 20 (18): 4859-64. PMID 1408801.
Wang L, Patel U, Ghosh L, Banerjee S (1992). "DNA polymerase beta mutations in human colorectal cancer.". Cancer Res. 52 (17): 4824-7. PMID 1511447.
Tokui T, Inagaki M, Nishizawa K, et al. (1991). "Inactivation of DNA polymerase beta by in vitro phosphorylation with protein kinase C.". J. Biol. Chem. 266 (17): 10820-4. PMID 2040602.
SenGupta DN, Zmudzka BZ, Kumar P, et al. (1986). "Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning.". Biochem. Biophys. Res. Commun. 136 (1): 341-7. PMID 2423078.
Zmudzka BZ, Fornace A, Collins J, Wilson SH (1988). "Characterization of DNA polymerase beta mRNA: cell-cycle and growth response in cultured human cells.". Nucleic Acids Res. 16 (20): 9587-96. PMID 2460824.
Widen SG, Kedar P, Wilson SH (1988). "Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter.". J. Biol. Chem. 263 (32): 16992-8. PMID 3182828.
Abbotts J, SenGupta DN, Zmudzka B, et al. (1988). "Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme.". Biochemistry 27 (3): 901-9. PMID 3284575.
Dobashi Y, Kubota Y, Shuin T, et al. (1995). "Polymorphisms in the human DNA polymerase beta gene.". Hum. Genet. 95 (4): 389-90. PMID 7705833.
Chyan YJ, Ackerman S, Shepherd NS, et al. (1994). "The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression.". Nucleic Acids Res. 22 (14): 2719-25. PMID 7914364.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Chang M, Burmer GC, Sweasy J, et al. (1994). "Evidence against DNA polymerase beta as a candidate gene for Werner syndrome.". Hum. Genet. 93 (5): 507-12. PMID 8168825.
Chyan YJ, Strauss PR, Wood TG, Wilson SH (1996). "Identification of novel mRNA isoforms for human DNA polymerase beta.". DNA Cell Biol. 15 (8): 653-9. PMID 8769567.
Pelletier H, Sawaya MR, Wolfle W, et al. (1996). "Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity.". Biochemistry 35 (39): 12742-61. doi:10.1021/bi952955d. PMID 8841118.
Pelletier H, Sawaya MR, Wolfle W, et al. (1996). "A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta.". Biochemistry 35 (39): 12762-77. doi:10.1021/bi9529566. PMID 8841119.
Pelletier H, Sawaya MR (1996). "Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis.". Biochemistry 35 (39): 12778-87. doi:10.1021/bi960790i. PMID 8841120.
Kubota Y, Nash RA, Klungland A, et al. (1997). "Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.". EMBO J. 15 (23): 6662-70. PMID 8978692.
Bennett RA, Wilson DM, Wong D, Demple B (1997). "Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7166-9. PMID 9207062.
Sawaya MR, Prasad R, Wilson SH, et al. (1997). "Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism.". Biochemistry 36 (37): 11205-15. doi:10.1021/bi9703812. PMID 9287163.
Bhattacharyya N, Banerjee S (1997). "A variant of DNA polymerase beta acts as a dominant negative mutant.". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10324-9. PMID 9294209.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.