DNA beta-glucosyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a DNA beta-glucosyltransferase (EC 2.4.1.27) is an enzyme that catalyzes the chemical reaction in which a beta-D-glucosyl residue is transferred from UDP-glucose to an hydroxymethylcytosine residue in DNA. It is analogous to the enzyme DNA alpha-glucosyltransferase.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:DNA beta-D-glucosyltransferase. Other names in common use include T4-HMC-beta-glucosyl transferase, T4-beta-glucosyl transferase, T4 phage beta-glucosyltransferase, UDP glucose-DNA beta-glucosyltransferase, and uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase.

[edit] Structural studies

As of late 2007, 20 structures have been solved for this class of enzymes, with PDB accession codes 1BGT, 1BGU, 1C3J, 1IXY, 1J39, 1JEJ, 1JG6, 1JG7, 1JIU, 1JIV, 1JIX, 1M5R, 1NVK, 1NZD, 1NZF, 1QKJ, 1SXP, 1SXQ, 2BGT, and 2BGU.

[edit] References

• IUBMB entry for 2.4.1.27
• BRENDA references for 2.4.1.27 (Recommended.)
• PubMed references for 2.4.1.27
• PubMed Central references for 2.4.1.27
• Google Scholar references for 2.4.1.27
• Kornberg SR, Zimmerman SB and Kornberg A (1961). "Glucosylation of deoxyribonucleic acid by enzymes from bacteriophage-infected Escherichia coli". J. Biol. Chem. 236: 1487–1493. 

[edit] External links

The CAS registry number for this enzyme class is 9030-14-2.

• IUBMB entry for 2.4.1.27

• KEGG entry for 2.4.1.27

• BRENDA entry for 2.4.1.27

• NiceZyme view of 2.4.1.27

• EC2PDB: PDB structures for 2.4.1.27

• PRIAM entry for 2.4.1.27

• PUMA2 entry for 2.4.1.27

• IntEnz: Integrated Enzyme entry for 2.4.1.27

• MetaCyc entry for 2.4.1.27

• Atomic-resolution structures of enzymes belonging to this class