DNASE1L1

From Wikipedia, the free encyclopedia

Deoxyribonuclease I-like 1

Identifiers

DNASE1L1; DNAS1L1; DNL1L; XIB

External IDs

OMIM: 300081 MGI: 109628 HomoloGene: 4896

Gene ontology
Molecular Function:	• DNA binding • endonuclease activity • deoxyribonuclease activity • hydrolase activity
Cellular Component:	• endoplasmic reticulum
Biological Process:	• DNA catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001009932 (mRNA)
NP_001009932 (protein)

NM_027109 (mRNA)
NP_081385 (protein)

Location

Chr X: 153.28 - 153.29 Mb

Chr X: 70.53 - 70.54 Mb

Pubmed search

[1]

[2]

Deoxyribonuclease I-like 1, also known as DNASE1L1, is a human gene.^[1]

This gene encodes a member of the deoxyribonuclease family and the protein shows high sequence similarity to lysosomal DNase I. Alternate transcriptional splice variants, encoding the same protein, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: DNASE1L1 deoxyribonuclease I-like 1.

[edit] Further reading

Parrish JE, Ciccodicola A, Wehhert M, et al. (1996). "A muscle-specific DNase I-like gene in human Xq28.". Hum. Mol. Genet. 4 (9): 1557–64. PMID 8541839.
Pergolizzi R, Appierto V, Bosetti A, et al. (1996). "Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region.". Gene 168 (2): 267–70. PMID 8654957.
Chen EY, Zollo M, Mazzarella R, et al. (1997). "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.". Hum. Mol. Genet. 5 (5): 659–68. PMID 8733135.
Rodriguez AM, Rodin D, Nomura H, et al. (1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I.". Genomics 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.
Malferrari G, Mazza U, Tresoldi C, et al. (1999). "Molecular characterization of a novel endonuclease (Xib) and possible involvement in lysosomal glycogen storage disorders.". Exp. Mol. Pathol. 66 (2): 123–30. doi:10.1006/exmp.1999.2254. PMID 10409440.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Shiokawa D, Shika Y, Saito K, et al. (2006). "Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X.". Biochem. J. 392 (Pt 3): 511–7. doi:10.1042/BJ20051114. PMID 16107205.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Coy JF, Velhagen I, Himmele R, et al.. "Isolation, differential splicing and protein expression of a DNase on the human X chromosome.". Cell Death Differ. 3 (2): 199–206. PMID 17180083.