DNAJC3

From Wikipedia, the free encyclopedia

DnaJ (Hsp40) homolog, subfamily C, member 3

Identifiers

DNAJC3; P58; HP58; P58IPK; PRKRI

External IDs

OMIM: 601184 MGI: 107373 HomoloGene: 2486

Gene ontology
Molecular Function:	• protein kinase inhibitor activity • binding • heat shock protein binding
Cellular Component:	• cytoplasm
Biological Process:	• protein folding • defense response • response to unfolded protein • response to virus

Orthologs

Human

Mouse

Refseq

NM_006260 (mRNA)
NP_006251 (protein)

NM_008929 (mRNA)
NP_032955 (protein)

Location

Chr 13: 95.13 - 95.25 Mb

Chr 14: 118.07 - 118.11 Mb

Pubmed search

[1]

[2]

DnaJ (Hsp40) homolog, subfamily C, member 3, also known as DNAJC3, is a human gene.^[1]

The protein encoded by this gene contains multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR).^[1]

[edit] References

^ ^a ^b Entrez Gene: DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3.

[edit] Further reading

Lee TG, Tang N, Thompson S, et al. (1994). "The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins.". Mol. Cell. Biol. 14 (4): 2331–42. PMID 7511204.
Polyak SJ, Tang N, Wambach M, et al. (1996). "The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity.". J. Biol. Chem. 271 (3): 1702–7. PMID 8576172.
Korth MJ, Lyons CN, Wambach M, Katze MG (1996). "Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase.". Gene 170 (2): 181–8. PMID 8666242.
Scherer SW, Duvoisin RM, Kuhn R, et al. (1997). "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.". Genomics 31 (2): 230–3. doi:10.1006/geno.1996.0036. PMID 8824806.
Korth MJ, Edelhoff S, Disteche CM, Katze MG (1997). "Chromosomal assignment of the gene encoding the human 58-kDa inhibitor (PRKRI) of the interferon-induced dsRNA-activated protein kinase to chromosome 13q32.". Genomics 31 (2): 238–9. doi:10.1006/geno.1996.0038. PMID 8824808.
Gale M, Blakely CM, Hopkins DA, et al. (1998). "Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK.". Mol. Cell. Biol. 18 (2): 859–71. PMID 9447982.
Melville MW, Tan SL, Wambach M, et al. (1999). "The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity.". J. Biol. Chem. 274 (6): 3797–803. PMID 9920933.
Ohtsuka K, Hata M (2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature.". Cell Stress Chaperones 5 (2): 98–112. PMID 11147971.
Horng T, Barton GM, Medzhitov R (2001). "TIRAP: an adapter molecule in the Toll signaling pathway.". Nat. Immunol. 2 (9): 835–41. doi:10.1038/ni0901-835. PMID 11526399.
Yan W, Gale MJ, Tan SL, Katze MG (2002). "Inactivation of the PKR protein kinase and stimulation of mRNA translation by the cellular co-chaperone P58(IPK) does not require J domain function.". Biochemistry 41 (15): 4938–45. PMID 11939789.
Ladiges W, Morton J, Hopkins H, et al. (2003). "Expression of human PKR protein kinase in transgenic mice.". J. Interferon Cytokine Res. 22 (3): 329–34. doi:10.1089/107999002753675758. PMID 12034040.
Yan W, Frank CL, Korth MJ, et al. (2003). "Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 15920–5. doi:10.1073/pnas.252341799. PMID 12446838.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
van Huizen R, Martindale JL, Gorospe M, Holbrook NJ (2003). "P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling.". J. Biol. Chem. 278 (18): 15558–64. doi:10.1074/jbc.M212074200. PMID 12601012.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.