DMRT1

From Wikipedia, the free encyclopedia


Doublesex and mab-3 related transcription factor 1
Identifiers
Symbol(s) DMRT1; DMT1
External IDs OMIM: 602424 MGI1354733 HomoloGene9280
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 1761 50796
Ensembl ENSG00000137090 ENSMUSG00000024837
Uniprot Q9Y5R6 Q19AV2
Refseq NM_021951 (mRNA)
NP_068770 (protein)
NM_015826 (mRNA)
NP_056641 (protein)
Location Chr 9: 0.83 - 0.96 Mb Chr 19: 25.57 - 25.67 Mb
Pubmed search [1] [2]

Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a human gene.[1]

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.[1]

[edit] References

[edit] Further reading

  • Raymond CS, Shamu CE, Shen MM, et al. (1998). "Evidence for evolutionary conservation of sex-determining genes.". Nature 391 (6668): 691-5. doi:10.1038/35618. PMID 9490411. 
  • Raymond CS, Parker ED, Kettlewell JR, et al. (1999). "A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators.". Hum. Mol. Genet. 8 (6): 989-96. PMID 10332030. 
  • Smith CA, McClive PJ, Western PS, et al. (2000). "Conservation of a sex-determining gene.". Nature 402 (6762): 601-2. doi:10.1038/45127. PMID 10604464. 
  • Calvari V, Bertini V, De Grandi A, et al. (2000). "A new submicroscopic deletion that refines the 9p region for sex reversal.". Genomics 65 (3): 203-12. doi:10.1006/geno.2000.6160. PMID 10857744. 
  • Muroya K, Okuyama T, Goishi K, et al. (2000). "Sex-determining gene(s) on distal 9p: clinical and molecular studies in six cases.". J. Clin. Endocrinol. Metab. 85 (9): 3094-100. PMID 10999792. 
  • Raymond CS, Murphy MW, O'Sullivan MG, et al. (2000). "Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation.". Genes Dev. 14 (20): 2587-95. PMID 11040213. 
  • Casci T (2001). "It's a guy thing.". Nat. Rev. Genet. 1 (3): 169. doi:10.1038/35042034. PMID 11252745. 
  • Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440-5. doi:10.1038/88107. PMID 11329013. 
  • Boyer A, Dornan S, Daneau I, et al. (2004). "Conservation of the function of DMRT1 regulatory sequences in mammalian sex differentiation.". Genesis 34 (4): 236-43. doi:10.1002/gene.10158. PMID 12434333. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Cheng HH, Ying M, Tian YH, et al. (2006). "Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis.". Cell Res. 16 (4): 389-93. doi:10.1038/sj.cr.7310050. PMID 16617334. 

[edit] External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.