DMP1 (gene)

From Wikipedia, the free encyclopedia

Dentin matrix acidic phosphoprotein
Identifiers
Symbol(s)	DMP1;
External IDs	OMIM: 600980 MGI: 94910 HomoloGene: 68396
Gene ontology Molecular Function: • integrin binding • calcium ion binding Cellular Component: • proteinaceous extracellular matrix Biological Process: • ossification • cell adhesion • extracellular matrix organization and biogenesis
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1758	13406
Ensembl	ENSG00000152592	ENSMUSG00000029307
Uniprot	Q13316	Q2HJ09
Refseq	NM_001079911 (mRNA) NP_001073380 (protein)	NM_016779 (mRNA) NP_058059 (protein)
Location	Chr 4: 88.79 - 88.8 Mb	Chr 5: 104.44 - 104.45 Mb
Pubmed search	[1]	[2]

Dentin matrix acidic phosphoprotein, also known as DMP1, is a human gene.^[1]

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.^[1]

[edit] References

[edit] Further reading