DMC1 (gene)

From Wikipedia, the free encyclopedia

DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)

PDB rendering based on 1v5w.

Available structures: 1v5w

Identifiers

Symbol(s)

DMC1; DMC1H; HsLim15; LIM15; MGC150472; MGC150473; dJ199H16.1

External IDs

OMIM: 602721 MGI: 105393 HomoloGene: 5135

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • ATP binding • DNA-dependent ATPase activity • nucleoside-triphosphatase activity
Cellular Component:	• condensed nuclear chromosome • intracellular • nucleus
Biological Process:	• ovarian follicle development • DNA metabolic process • cell cycle • meiosis • meiotic recombination • spermatogenesis • female gamete generation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007068 (mRNA)
NP_008999 (protein)

NM_010059 (mRNA)
NP_034189 (protein)

Location

Chr 22: 37.24 - 37.3 Mb

Chr 15: 79.39 - 79.43 Mb

Pubmed search

[1]

[2]

DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast), also known as DMC1, is a human gene.^[1]

The protein encoded by this gene is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this gene is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes. Alternative splice variants of this gene have been described but their full-length nature has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: DMC1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast).

[edit] Further reading

Sato S, Seki N, Hotta Y, Tabata S (1996). "Expression profiles of a human gene identified as a structural homologue of meiosis-specific recA-like genes.". DNA Res. 2 (4): 183-6. PMID 8590282.
Habu T, Taki T, West A, et al. (1996). "The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis.". Nucleic Acids Res. 24 (3): 470-7. PMID 8602360.
Golub EI, Gupta RC, Haaf T, et al. (1999). "Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA.". Nucleic Acids Res. 26 (23): 5388-93. PMID 9826763.
Masson JY, Davies AA, Hajibagheri N, et al. (2000). "The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.". EMBO J. 18 (22): 6552-60. doi:10.1093/emboj/18.22.6552. PMID 10562567.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Moens PB, Kolas NK, Tarsounas M, et al. (2003). "The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination.". J. Cell. Sci. 115 (Pt 8): 1611-22. PMID 11950880.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Habu T, Wakabayashi N, Yoshida K, et al. (2004). "p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis.". Carcinogenesis 25 (6): 889-93. doi:10.1093/carcin/bgh099. PMID 14764457.
Kinebuchi T, Kagawa W, Enomoto R, et al. (2004). "Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1.". Mol. Cell 14 (3): 363-74. PMID 15125839.
Sehorn MG, Sigurdsson S, Bussen W, et al. (2004). "Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange.". Nature 429 (6990): 433-7. doi:10.1038/nature02563. PMID 15164066.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kinebuchi T, Kagawa W, Kurumizaka H, Yokoyama S (2005). "Role of the N-terminal domain of the human DMC1 protein in octamer formation and DNA binding.". J. Biol. Chem. 280 (31): 28382-7. doi:10.1074/jbc.M503372200. PMID 15917243.
Bugreev DV, Golub EI, Stasiak AZ, et al. (2005). "Activation of human meiosis-specific recombinase Dmc1 by Ca2+.". J. Biol. Chem. 280 (29): 26886-95. doi:10.1074/jbc.M502248200. PMID 15917244.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Thorslund T, Esashi F, West SC (2007). "Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1.". EMBO J. 26 (12): 2915-22. doi:10.1038/sj.emboj.7601739. PMID 17541404.
Pezza RJ, Voloshin ON, Vanevski F, Camerini-Otero RD (2007). "Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing.". Genes Dev. 21 (14): 1758-66. doi:10.1101/gad.1562907. PMID 17639081.