DMAP1

From Wikipedia, the free encyclopedia

DNA methyltransferase 1 associated protein 1

Identifiers

DMAP1; EAF2; DKFZp686L09142; DNMAP1; DNMTAP1; FLJ11543; KIAA1425; SWC4

External IDs

OMIM: 605077 MGI: 1913483 HomoloGene: 41311

Gene ontology
Molecular Function:	• DNA binding • protein binding • methyltransferase activity • transcription repressor activity • transferase activity
Cellular Component:	• nucleus
Biological Process:	• regulation of cell growth • DNA methylation • transcription • regulation of transcription, DNA-dependent • negative regulation of transcription • chromatin modification

Orthologs

Human

Mouse

Refseq

NM_001034023 (mRNA)
NP_001029195 (protein)

NM_023178 (mRNA)
NP_075667 (protein)

Location

Chr 1: 44.45 - 44.46 Mb

Chr 4: 117.17 - 117.18 Mb

Pubmed search

[1]

[2]

DNA methyltransferase 1 associated protein 1, also known as DMAP1, is a human gene.^[1]

This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: DMAP1 DNA methyltransferase 1 associated protein 1.

[edit] Further reading

Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex.". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. PMID 10718198.
Rountree MR, Bachman KE, Baylin SB (2000). "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.". Nat. Genet. 25 (3): 269–77. doi:10.1038/77023. PMID 10888872.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol.". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
Xin H, Yoon HG, Singh PB, et al. (2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells.". J. Biol. Chem. 279 (10): 9539–46. doi:10.1074/jbc.M311587200. PMID 14665632.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Liu Z, Fisher RA (2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity.". J. Biol. Chem. 279 (14): 14120–8. doi:10.1074/jbc.M309547200. PMID 14734556.
Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.". Mol. Cell. Biol. 24 (5): 1884–96. PMID 14966270.
Muromoto R, Sugiyama K, Takachi A, et al. (2004). "Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1.". J. Immunol. 172 (5): 2985–93. PMID 14978102.
Muromoto R, Sugiyama K, Yamamoto T, et al. (2004). "Physical and functional interactions between Daxx and TSG101.". Biochem. Biophys. Res. Commun. 316 (3): 827–33. doi:10.1016/j.bbrc.2004.02.126. PMID 15033475.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Delgermaa L, Hayashi N, Dorjsuren D, et al. (2004). "Subcellular localization of RPB5-mediating protein and its putative functional partner.". Mol. Cell. Biol. 24 (19): 8556–66. doi:10.1128/MCB.24.19.8556-8566.2004. PMID 15367675.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.