DLX6

From Wikipedia, the free encyclopedia

Distal-less homeobox 6

Identifiers

DLX6; MGC125282; MGC125283; MGC125284; MGC125285

External IDs

Gene ontology
Molecular Function:	• transcription factor activity • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• skeletal development • regulation of transcription, DNA-dependent • multicellular organismal development • nervous system development • embryonic limb morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_005222 (mRNA)
NP_005213 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 7: 96.47 - 96.48 Mb

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Pubmed search

[1]

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Distal-less homeobox 6, also known as DLX6, is a human gene.^[1]

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7.^[1]

[edit] References

^ ^a ^b Entrez Gene: DLX6 distal-less homeobox 6.

[edit] Further reading

Simeone A, Acampora D, Pannese M, et al. (1994). "Cloning and characterization of two members of the vertebrate Dlx gene family.". Proc. Natl. Acad. Sci. U.S.A. 91 (6): 2250–4. PMID 7907794.
Crackower MA, Scherer SW, Rommens JM, et al. (1997). "Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development.". Hum. Mol. Genet. 5 (5): 571–9. PMID 8733122.
Charité J, McFadden DG, Merlo G, et al. (2001). "Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer.". Genes Dev. 15 (22): 3039–49. doi:10.1101/gad.931701. PMID 11711438.
Depew MJ, Lufkin T, Rubenstein JL (2002). "Specification of jaw subdivisions by Dlx genes.". Science 298 (5592): 381–5. doi:10.1126/science.1075703. PMID 12193642.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nabi R, Zhong H, Serajee FJ, Huq AH (2004). "No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 119 (1): 98–101. doi:10.1002/ajmg.b.10012. PMID 12707945.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Schüle B, Li HH, Fisch-Kohl C, et al. (2007). "DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency.". Am. J. Hum. Genet. 81 (3): 492–506. doi:10.1086/520063. PMID 17701895.