DLK1

From Wikipedia, the free encyclopedia

Delta-like 1 homolog (Drosophila)

Identifiers

DLK1; FA1; PREF1; Pref-1; ZOG; pG2

External IDs

OMIM: 176290 MGI: 94900 HomoloGene: 2846

Gene ontology
Molecular Function:	• molecular_function • protein binding
Cellular Component:	• extracellular space • soluble fraction • membrane • integral to membrane
Biological Process:	• multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001032997 (mRNA)
NP_001028169 (protein)

NM_010052 (mRNA)
NP_034182 (protein)

Location

Chr 14: 100.26 - 100.27 Mb

Chr 12: 109.9 - 109.91 Mb

Pubmed search

[1]

[2]

Delta-like 1 homolog (Drosophila), also known as DLK1, is a human gene.^[1]

[edit] References

^ Entrez Gene: DLK1 delta-like 1 homolog (Drosophila).

[edit] Further reading

Helman LJ, Sack N, Plon SE, Israel MA (1990). "The sequence of an adrenal specific human cDNA, pG2.". Nucleic Acids Res. 18 (3): 685. PMID 2308864.
Helman LJ, Thiele CJ, Linehan WM, et al. (1987). "Molecular markers of neuroendocrine development and evidence of environmental regulation.". Proc. Natl. Acad. Sci. U.S.A. 84 (8): 2336–9. PMID 3470797.
Lee YL, Helman L, Hoffman T, Laborda J (1995). "dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA.". Biochim. Biophys. Acta 1261 (2): 223–32. PMID 7711066.
Jensen CH, Krogh TN, Højrup P, et al. (1994). "Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2.". Eur. J. Biochem. 225 (1): 83–92. PMID 7925474.
Laborda J, Sausville EA, Hoffman T, Notario V (1993). "dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line.". J. Biol. Chem. 268 (6): 3817–20. PMID 8095043.
Smas CM, Sul HS (1993). "Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation.". Cell 73 (4): 725–34. PMID 8500166.
Jensen CH, Teisner B, Højrup P, et al. (1993). "Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2.". Hum. Reprod. 8 (4): 635–41. PMID 8501199.
Tornehave D, Jensen CH, Teisner B, Larsson LI (1997). "FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression.". Histochem. Cell Biol. 106 (6): 535–42. PMID 8985741.
Jensen CH, Schroder HD, Teisner B, et al. (2000). "Fetal antigen 1, a member of the epidermal growth factor superfamily, in neurofibromas and serum from patients with neurofibromatosis type 1.". Br. J. Dermatol. 140 (6): 1054–9. PMID 10354070.
Gubina E, Ruiz-Hidalgo MJ, Baladrón V, Laborda J (1999). "Assignment of DLK1 to human chromosome band 14q32 by in situ hybridization.". Cytogenet. Cell Genet. 84 (3-4): 206–7. PMID 10393432.
Jensen CH, Erb K, Westergaard LG, et al. (1999). "Fetal antigen 1, an EGF multidomain protein in the sex hormone-producing cells of the gonads and the microenvironment of germ cells.". Mol. Hum. Reprod. 5 (10): 908–13. PMID 10508217.
Aguan K, Carvajal JA, Thompson LP, Weiner CP (2001). "Application of a functional genomics approach to identify differentially expressed genes in human myometrium during pregnancy and labour.". Mol. Hum. Reprod. 6 (12): 1141–5. PMID 11101697.
Andersen M, Jensen CH, Støving RK, et al. (2001). "Fetal antigen 1 in healthy adults and patients with pituitary disease: relation to physiological, pathological, and pharmacological GH levels.". J. Clin. Endocrinol. Metab. 86 (11): 5465–70. PMID 11701723.
Jensen CH, Meyer M, Schroder HD, et al. (2002). "Neurons in the monoaminergic nuclei of the rat and human central nervous system express FA1/dlk.". Neuroreport 12 (18): 3959–63. PMID 11742219.
Baladrón V, Ruiz-Hidalgo MJ, Bonvini E, et al. (2002). "The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system.". Biochem. Biophys. Res. Commun. 291 (2): 193–204. doi:10.1006/bbrc.2002.6431. PMID 11846389.
Panin VM, Shao L, Lei L, et al. (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe.". J. Biol. Chem. 277 (33): 29945–52. doi:10.1074/jbc.M204445200. PMID 12036964.
Doggett KL, Briggs JA, Linton MF, et al. (2002). "Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression.". J. Cell. Biochem. 86 (1): 56–66. doi:10.1002/jcb.10190. PMID 12112016.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Van Limpt VA, Chan AJ, Van Sluis PG, et al. (2003). "High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type.". Int. J. Cancer 105 (1): 61–9. doi:10.1002/ijc.11047. PMID 12672031.
Abdallah BM, Jensen CH, Gutierrez G, et al. (2004). "Regulation of human skeletal stem cells differentiation by Dlk1/Pref-1.". J. Bone Miner. Res. 19 (5): 841–52. doi:10.1359/JBMR.040118. PMID 15068508.