DLGAP2

From Wikipedia, the free encyclopedia

Discs, large (Drosophila) homolog-associated protein 2

Identifiers

DLGAP2; DAP2; SAPAP2

External IDs

OMIM: 605438 MGI: 2443181 HomoloGene: 3484

Gene ontology
Molecular Function:	• transcription factor activity • steroid hormone receptor activity • protein binding
Cellular Component:	• nucleus • neurofilament • membrane
Biological Process:	• regulation of transcription, DNA-dependent • cell-cell signaling • nerve-nerve synaptic transmission

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004745 (mRNA)
NP_004736 (protein)

NM_172910 (mRNA)
NP_766498 (protein)

Location

Chr 8: 1.44 - 1.64 Mb

Chr 8: 14.53 - 14.85 Mb

Pubmed search

[1]

[2]

Discs, large (Drosophila) homolog-associated protein 2, also known as DLGAP2, is a human gene.^[1]

The product of this gene is one of the membrane-associated guanylate kinases localized at postsynaptic density in neuronal cells. These kinases are a family of signaling molecules expressed at various submembrane domains and contain the PDZ, SH3 and the guanylate kinase domains. This protein may play a role in the molecular organization of synapses and in neuronal cell signaling. Alternatively spliced transcript variants encoding different isoforms have been identified, but their full-length nature is not known.^[1]

[edit] References

^ ^a ^b Entrez Gene: DLGAP2 discs, large (Drosophila) homolog-associated protein 2.

[edit] Further reading

Takeuchi M, Hata Y, Hirao K, et al. (1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.". J. Biol. Chem. 272 (18): 11943–51. PMID 9115257.
Naisbitt S, Kim E, Weinberg RJ, et al. (1997). "Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90.". J. Neurosci. 17 (15): 5687–96. PMID 9221768.
Satoh K, Yanai H, Senda T, et al. (1997). "DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95.". Genes Cells 2 (6): 415–24. PMID 9286858.
Ranta S, Lehesjoki AE, de Fatima Bonaldo M, et al. (1997). "High-resolution mapping and transcript identification at the progressive epilepsy with mental retardation locus on chromosome 8p.". Genome Res. 7 (9): 887–96. PMID 9314494.
Hirao K, Hata Y, Ide N, et al. (1998). "A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins.". J. Biol. Chem. 273 (33): 21105–10. PMID 9694864.
Kawabe H, Hata Y, Takeuchi M, et al. (1999). "nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP).". J. Biol. Chem. 274 (43): 30914–8. PMID 10521485.
Hirao K, Hata Y, Deguchi M, et al. (2000). "Association of synapse-associated protein 90/ postsynaptic density-95-associated protein (SAPAP) with neurofilaments.". Genes Cells 5 (3): 203–10. PMID 10759891.
Wang P, Zhang Q, Tochio H, et al. (2000). "Formation of a native-like beta-hairpin finger structure of a peptide from the extended PDZ domain of neuronal nitric oxide synthase in aqueous solution.". Eur. J. Biochem. 267 (11): 3116–22. PMID 10824095.
Ranta S, Zhang Y, Ross B, et al. (2000). "Positional cloning and characterisation of the human DLGAP2 gene and its exclusion in progressive epilepsy with mental retardation.". Eur. J. Hum. Genet. 8 (5): 381–4. doi:10.1038/sj.ejhg.5200440. PMID 10854099.
Bolliger MF, Frei K, Winterhalter KH, Gloor SM (2001). "Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression.". Biochem. J. 356 (Pt 2): 581–8. PMID 11368788.
Hu LA, Chen W, Premont RT, et al. (2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95.". J. Biol. Chem. 277 (2): 1607–13. doi:10.1074/jbc.M107297200. PMID 11700307.
Ohtakara K, Nishizawa M, Izawa I, et al. (2003). "Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1.". Genes Cells 7 (11): 1149–60. PMID 12390249.
Verhoeven K, De Jonghe P, Van de Putte T, et al. (2003). "Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10.". Am. J. Hum. Genet. 73 (4): 926–32. doi:10.1086/378159. PMID 14508709.
Ying Z, Bingaman W, Najm IM (2004). "Increased numbers of coassembled PSD-95 to NMDA-receptor subunits NR2B and NR1 in human epileptic cortical dysplasia.". Epilepsia 45 (4): 314–21. doi:10.1111/j.0013-9580.2004.37703.x. PMID 15030493.