DLG7

From Wikipedia, the free encyclopedia

Discs, large homolog 7 (Drosophila)

Identifiers

DLG7; DLG1; HURP; KIAA0008

External IDs

Gene ontology
Molecular Function:	• phosphoprotein phosphatase activity • protein binding
Cellular Component:	• nucleus • spindle pole centrosome
Biological Process:	• M phase of mitotic cell cycle • cell cycle • mitotic chromosome movement towards spindle pole • cell-cell signaling • cell proliferation • positive regulation of mitotic metaphase/anaphase transition

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014750 (mRNA)
NP_055565 (protein)

NM_144553 (mRNA)
NP_653136 (protein)

Location

Chr 14: 54.68 - 54.73 Mb

Chr 14: 46.31 - 46.34 Mb

Pubmed search

[1]

[2]

Discs, large homolog 7 (Drosophila), also known as DLG7, is a human gene.^[1]

[edit] References

^ Entrez Gene: DLG7 discs, large homolog 7 (Drosophila).

[edit] Further reading

Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.". DNA Res. 1 (1): 27–35. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47–56. PMID 7584028.
Ohara O, Nagase T, Ishikawa K, et al. (1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.". DNA Res. 4 (1): 53–9. PMID 9179496.
Bassal S, Nomura N, Venter D, et al. (2001). "Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1.". Genomics 77 (1-2): 5–7. doi:10.1006/geno.2001.6570. PMID 11543626.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tsou AP, Yang CW, Huang CY, et al. (2003). "Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma.". Oncogene 22 (2): 298–307. doi:10.1038/sj.onc.1206129. PMID 12527899.
Mantovani F, Banks L (2004). "Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor.". J. Biol. Chem. 278 (43): 42477–86. doi:10.1074/jbc.M302799200. PMID 12902344.
Laprise P, Viel A, Rivard N (2004). "Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells.". J. Biol. Chem. 279 (11): 10157–66. doi:10.1074/jbc.M309843200. PMID 14699157.
Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.". Mol. Cell Proteomics 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
Hsu JM, Lee YC, Yu CT, Huang CY (2004). "Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.". J. Biol. Chem. 279 (31): 32592–602. doi:10.1074/jbc.M404950200. PMID 15145941.
Blot V, Delamarre L, Perugi F, et al. (2005). "Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes.". J. Cell. Sci. 117 (Pt 17): 3983–93. doi:10.1242/jcs.01266. PMID 15286176.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Zhao L, Qin LX, Ye QH, et al. (2005). "KIAA0008 gene is associated with invasive phenotype of human hepatocellular carcinoma--a functional analysis.". J. Cancer Res. Clin. Oncol. 130 (12): 719–27. doi:10.1007/s00432-004-0595-2. PMID 15340842.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Yu CT, Hsu JM, Lee YC, et al. (2005). "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A.". Mol. Cell. Biol. 25 (14): 5789–800. doi:10.1128/MCB.25.14.5789-5800.2005. PMID 15987997.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
Wong J, Fang G (2006). "HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.". J. Cell Biol. 173 (6): 879–91. doi:10.1083/jcb.200511132. PMID 16769820.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.