DLG1

From Wikipedia, the free encyclopedia

Discs, large homolog 1 (Drosophila)

PDB rendering based on 1iu0.

Available structures: 1iu0, 1iu2, 1kef, 1pdr, 1rgr, 1rso, 1zok, 2awu, 2aww, 2awx, 2g2l, 2i0i, 2i0l

Identifiers

Symbol(s)

DLG1; DKFZp761P0818; DLGH1; SAP97; dJ1061C18.1.1; hdlg

External IDs

OMIM: 601014 MGI: 107231 HomoloGene: 20869

Gene ontology
Molecular Function:	• guanylate kinase activity • phosphoprotein phosphatase activity • protein C-terminus binding • cytoskeletal protein binding • potassium channel regulator activity • protein kinase binding • phosphatase binding
Cellular Component:	• endoplasmic reticulum • plasma membrane • cell-cell adherens junction • basolateral plasma membrane
Biological Process:	• endothelial cell proliferation • actin filament organization • establishment and/or maintenance of cell polarity • cell-cell adhesion • cortical actin cytoskeleton organization and biogenesis • G1/S transition checkpoint • positive regulation of body size • negative regulation of progression through mitotic cell cycle • positive regulation of developmental growth

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004087 (mRNA)
NP_004078 (protein)

XM_001000012 (mRNA)
XP_001000012 (protein)

Location

Chr 3: 198.26 - 198.51 Mb

Chr 16: 31.58 - 31.79 Mb

Pubmed search

[1]

[2]

Discs, large homolog 1 (Drosophila), also known as DLG1, is a human gene.

[edit] Further reading

Humbert P, Russell S, Richardson H (2003). "Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer.". Bioessays 25 (6): 542–53. doi:10.1002/bies.10286. PMID 12766944.
Mukherjee A, Varma SK, Natarajan K (1972). "Ankle joint instability in poliomyelitis.". Indian journal of pediatrics 39 (289): 37–8. PMID 5024025.
Kim E, Niethammer M, Rothschild A, et al. (1995). "Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.". Nature 378 (6552): 85–8. doi:10.1038/378085a0. PMID 7477295.
Lue RA, Marfatia SM, Branton D, Chishti AH (1994). "Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.". Proc. Natl. Acad. Sci. U.S.A. 91 (21): 9818–22. PMID 7937897.
Niethammer M, Kim E, Sheng M (1996). "Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases.". J. Neurosci. 16 (7): 2157–63. PMID 8601796.
Azim AC, Knoll JH, Marfatia SM, et al. (1997). "DLG1: chromosome location of the closest human homologue of the Drosophila discs large tumor suppressor gene.". Genomics 30 (3): 613–6. doi:10.1006/geno.1995.1286. PMID 8825652.
Lue RA, Brandin E, Chan EP, Branton D (1997). "Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain.". J. Cell Biol. 135 (4): 1125–37. PMID 8922391.
Takeuchi M, Hata Y, Hirao K, et al. (1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.". J. Biol. Chem. 272 (18): 11943–51. PMID 9115257.
Horio Y, Hibino H, Inanobe A, et al. (1997). "Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1, by an anchoring protein, PSD-95/SAP90.". J. Biol. Chem. 272 (20): 12885–8. PMID 9148889.
Lee SS, Weiss RS, Javier RT (1997). "Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6670–5. PMID 9192623.
Satoh K, Yanai H, Senda T, et al. (1997). "DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95.". Genes Cells 2 (6): 415–24. PMID 9286858.
Hanada T, Lin L, Chandy KG, et al. (1997). "Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes.". J. Biol. Chem. 272 (43): 26899–904. PMID 9341123.
Reuver SM, Garner CC (1998). "E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton.". J. Cell. Sci. 111 ( Pt 8): 1071–80. PMID 9512503.
Leonard AS, Davare MA, Horne MC, et al. (1998). "SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit.". J. Biol. Chem. 273 (31): 19518–24. PMID 9677374.
Deguchi M, Hata Y, Takeuchi M, et al. (1998). "BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein.". J. Biol. Chem. 273 (41): 26269–72. PMID 9756850.
Brenman JE, Topinka JR, Cooper EC, et al. (1998). "Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A.". J. Neurosci. 18 (21): 8805–13. PMID 9786987.
Bassand P, Bernard A, Rafiki A, et al. (1999). "Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97.". Eur. J. Neurosci. 11 (6): 2031–43. PMID 10336672.
Firestein BL, Firestein BL, Brenman JE, et al. (2000). "Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting.". Neuron 24 (3): 659–72. PMID 10595517.
Hibino H, Inanobe A, Tanemoto M, et al. (2000). "Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain.". EMBO J. 19 (1): 78–83. doi:10.1093/emboj/19.1.78. PMID 10619846.
Adey NB, Huang L, Ormonde PA, et al. (2000). "Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding.". Cancer Res. 60 (1): 35–7. PMID 10646847.