Talk:Dissociative drug

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[edit] Text removed from Psychedelic drug page, to be edited and added to this page

The following text was erroneously added to the psychedelic drug page:

Salvia divinorum produces two potent dissociative drugs: The Salvinorins A and B.

---Dissociatives ([NMDA and PCP receptor agonists/antagonists])---

Ketamine and its parent drug phencylcidine are somatically safe and useful anaesthetics. Ketamine, specially, is used for psychedelic and more general therapeutic purposes (as in the studies by Dr Evgeny Krupitsky of Russia, cited in www.maps.org/research/ketamine/ketrussia.html). It´s considered a promising new pharmacological approach to the treatment of chronic alcoholism. Dextromethorphan (DXM), which is a synthetic opioid, has also some hallucinogenic propoerties at doses much higher than those used as cough suppresant, though more possibly it acts through a different mechanism than PCP and ketamine, and it´s also more prone to cause actual neuronal death in a fashion similar to alcohol. It is an uncontrolled substance in much countries, as is usually the case with disagreeable and noxious substances. It is sold Over the Counter in most of the United States. Contrary to dangerous psychotropics or poisonous substances as paraquat, which remain legal, safe psychodelic substances are severly punished by repressive forces, according to the plan for the extinction of certain drugs that the government of the United States enacts since the foundation of the United Nations, specially through the UN´s Bureau of Narcotics. Dangerous or poisonous substances remin uncontrolled, in an world UN´s sponsored effort to make users seeking mind expansion to be intoxicated with substances that deteriorate their minds. The plan of the United States has been denounced as an actual attempt of reducing the recreative drugs available to those that generate serious deleterous addiction (specially brain damage, dementia, or acquired mental retardation) in order to increase the gobernability and submission of the people of the world to the suppliers of the Official American Drugs: Alcohol, tobacco, many pharmaceuticals such as the benzodiazepines.

[edit] Nitrous Oxide

From the page Effects of nitrous oxide on the body, "It (N2O) inhibits the NMDA receptor at partial pressures similar to those used in general anaesthesia (Jevtovic-Todorovic et al., 1998; Mennerick et al., 1998; Yamakura & Harris, 2000)." Therefore, I think that N2O should not be classified as an inhalant (which merely discribes its method of intake) and move it under NMDA Receptor Antagonists. I'll move this but I'm open to discussion if anyone believes otherwise.

Also, this opens the possibility of N2O causing Olney's Lesions. However, it is possible that it does not cause cellular vacuolization because of its effect on the GABA receptor (and inhibiting the GABA receptor helps prevent vacuolization.) Either way, I'd like someone more qualified than me to verify both my changing of its classification and the possibility of Olney's Lesions. Jolb 23:25, 16 January 2007 (UTC)