Diphthine-ammonia ligase

From Wikipedia, the free encyclopedia

In enzymology, a diphthine-ammonia ligase (EC 6.3.2.22) is an enzyme that catalyzes the chemical reaction

ATP + diphthine + NH₃ ADP + phosphate + diphthamide

The 3 substrates of this enzyme are ATP, diphthine, and NH₃, whereas its 3 products are ADP, phosphate, and diphthamide.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is diphthine:ammonia ligase (ADP-forming). Other names in common use include diphthamide synthase, and diphthamide synthetase.

[edit] References

• IUBMB entry for 6.3.2.22
• BRENDA references for 6.3.2.22 (Recommended.)
• PubMed references for 6.3.2.22
• PubMed Central references for 6.3.2.22
• Google Scholar references for 6.3.2.22
• Moehring JM, Moehring TJ (1988). "The post-translational trimethylation of diphthamide studied in vitro". J. Biol. Chem. 263: 3840–4. PMID 3346227. 
• Moehring TJ and Moehring JM (1987). "Mutant cultured cells used to study the synthesis of diphthamide". UCLA Symp. Mol. Cell. Biol. New Ser. 45: 53–63. 

[edit] External links

The CAS registry number for this enzyme class is 114514-33-9.

• IUBMB entry for 6.3.2.22

• KEGG entry for 6.3.2.22

• BRENDA entry for 6.3.2.22

• NiceZyme view of 6.3.2.22

• EC2PDB: PDB structures for 6.3.2.22

• PRIAM entry for 6.3.2.22

• PUMA2 entry for 6.3.2.22

• IntEnz: Integrated Enzyme entry for 6.3.2.22

• MetaCyc entry for 6.3.2.22

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0017178: diphthine-ammonia ligase

• AMIGO entry for GO code 0017178: diphthine-ammonia ligase