Diphosphoinositol-pentakisphosphate kinase

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In enzymology, a diphosphoinositol-pentakisphosphate kinase (EC 2.7.4.24) is an enzyme that catalyzes the chemical reaction

ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown)

Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 5-diphosphate pentakisphosphate, whereas its 3 products are ADP, 1D-myo-inositol bisdiphosphate tetrakisphosphate and (isomeric configuration unknown).

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol-5-diphosphate-pentakisphosphate phosphotransferase. Other names in common use include PP-IP5 kinase, diphosphoinositol pentakisphosphate kinase, and ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase.

[edit] References

• IUBMB entry for 2.7.4.24
• BRENDA references for 2.7.4.24 (Recommended.)
• PubMed references for 2.7.4.24
• PubMed Central references for 2.7.4.24
• Google Scholar references for 2.7.4.24
• Shears SB, Ali N, Craxton A, Bembenek ME (1995). "Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo". J. Biol. Chem. 270: 10489–97. doi:10.1074/jbc.270.18.10489. PMID 7737983. 
• Brocker M, Shears SB, Mayr GW (Pt 2). "Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells". Biochem. J. 327: 553–60. PMID 9359429. 

[edit] External links

• IUBMB entry for 2.7.4.24

• KEGG entry for 2.7.4.24

• BRENDA entry for 2.7.4.24

• NiceZyme view of 2.7.4.24

• EC2PDB: PDB structures for 2.7.4.24

• PRIAM entry for 2.7.4.24

• PUMA2 entry for 2.7.4.24

• IntEnz: Integrated Enzyme entry for 2.7.4.24

• MetaCyc entry for 2.7.4.24

• Atomic-resolution structures of enzymes belonging to this class