Diphosphate-fructose-6-phosphate 1-phosphotransferase

From Wikipedia, the free encyclopedia

In enzymology, a diphosphate-fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90) is an enzyme that catalyzes the chemical reaction

diphosphate + D-fructose 6-phosphate $\rightleftharpoons$ phosphate + D-fructose 1,6-bisphosphate

Thus, the two substrates of this enzyme are diphosphate and D-fructose 6-phosphate, whereas its two products are phosphate and D-fructose 1,6-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is diphosphate:D-fructose-6-phosphate 1-phosphotransferase. Other names in common use include 6-phosphofructokinase (pyrophosphate), pyrophosphate-fructose 6-phosphate 1-phosphotransferase, inorganic pyrophosphate-dependent phosphofructokinase, inorganic pyrophosphate-phosphofructokinase, pyrophosphate-dependent phosphofructo-1-kinase, and pyrophosphate-fructose 6-phosphate phosphotransferase. This enzyme participates in fructose and mannose metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1KZH and 2F48.

[edit] References

IUBMB entry for 2.7.1.90
BRENDA references for 2.7.1.90 (Recommended.)
PubMed references for 2.7.1.90
PubMed Central references for 2.7.1.90
Google Scholar references for 2.7.1.90
Reeves RE, Serrano R, South DJ (1976). "6-phosphofructokinase (pyrophosphate). Properties of the enzyme from Entamoeba histolytica and its reaction mechanism". J. Biol. Chem. 251: 2958–62. PMID 178659.
Reeves RE, South DJ, Blytt HJ, Warren LG (1974). "Pyrophosphate:D-fructose 6-phosphate 1-phosphotransferase. A new enzyme with the glycolytic function of 6-phosphofructokinase". J. Biol. Chem. 249: 7737–41. PMID 4372217.