Dinoprostone
From Wikipedia, the free encyclopedia
Not to be confused with Dinoprost.
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Dinoprostone
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| Systematic (IUPAC) name | |
| 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)- 5-oxo-cyclopentyl] hept-5-enoic acid | |
| Identifiers | |
| CAS number | |
| ATC code | G02 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C20H32O5 |
| Mol. mass | 352.465 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
In medicine, dinoprostone, is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour and also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts.
It is sold under the trade name of Cervidil (by Forest Laboratories, Inc.), Prostin E2 (by Pfizer Inc.) and Propess (by Ferring Pharmaceuticals), as a vaginal suppository, to prepare the cervix for labour; it is used to induce labour.
The chemical name is (5Z,11(alpha),13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid.
Like other prostaglandins, dinoprostone can be used as an abortifacient.
It works by binding and activating the prostaglandin E2 receptor.
[edit] External links
- Dinoprostone - medlineplus.org
- Cervidil - Forest Laboratories, Inc. (the distributor of Cervidil).
- Prostin E2 - pfizer.com
- Cervidil/Prostin E2 - RxList.com
- What is Cervidil? - birthingnaturally.net.
- Cervidil/Prostin E2 - drugs.com
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