Dimethylmaleate hydratase

From Wikipedia, the free encyclopedia

In enzymology, a dimethylmaleate hydratase (EC 4.2.1.85) is an enzyme that catalyzes the chemical reaction

(2R,3S)-2,3-dimethylmalate dimethylmaleate + H₂O

Hence, this enzyme has one substrate, (2R,3S)-2,3-dimethylmalate, and two products, dimethylmaleate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming). This enzyme is also called (2R,3S)-2,3-dimethylmalate hydro-lyase. This enzyme participates in c5-branched dibasic acid metabolism. It employs one cofactor, iron.

[edit] References

• IUBMB entry for 4.2.1.85
• BRENDA references for 4.2.1.85 (Recommended.)
• PubMed references for 4.2.1.85
• PubMed Central references for 4.2.1.85
• Google Scholar references for 4.2.1.85
• Kollmann-Koch A, Eggerer H (1984). "Nicotinic acid metabolism. Dimethylmaleate hydratase". Hoppe. Seylers. Z. Physiol. Chem. 365: 847–57. PMID 6489933. 

[edit] External links

The CAS registry number for this enzyme class is 93229-56-2.

• IUBMB entry for 4.2.1.85

• KEGG entry for 4.2.1.85

• BRENDA entry for 4.2.1.85

• NiceZyme view of 4.2.1.85

• EC2PDB: PDB structures for 4.2.1.85

• PRIAM entry for 4.2.1.85

• PUMA2 entry for 4.2.1.85

• IntEnz: Integrated Enzyme entry for 4.2.1.85

• MetaCyc entry for 4.2.1.85

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047868: dimethylmaleate hydratase

• AMIGO entry for GO code 0047868: dimethylmaleate hydratase