Dimethylmalate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a dimethylmalate dehydrogenase (EC 1.1.1.84) is an enzyme that catalyzes the chemical reaction

(R)-3,3-dimethylmalate + NAD⁺ 3-methyl-2-oxobutanoate + CO₂ + NADH

Thus, the two substrates of this enzyme are (R)-3,3-dimethylmalate and NAD⁺, whereas its 3 products are 3-methyl-2-oxobutanoate, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating). This enzyme is also called beta,beta-dimethylmalate dehydrogenase. This enzyme participates in pantothenate and coa biosynthesis. It has 5 cofactors: NH3, Manganese, Cobalt, Potassium, and NH4+.

[edit] References

• IUBMB entry for 1.1.1.84
• BRENDA references for 1.1.1.84 (Recommended.)
• PubMed references for 1.1.1.84
• PubMed Central references for 1.1.1.84
• Google Scholar references for 1.1.1.84
• Magee PT, Snell EE (1966). "The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to alpha-ketoisovalerate". Biochemistry. 5: 409–16. doi:10.1021/bi00866a004. PMID 4287371. 

[edit] External links

The CAS registry number for this enzyme class is 37250-21-8.

• IUBMB entry for 1.1.1.84

• KEGG entry for 1.1.1.84

• BRENDA entry for 1.1.1.84

• NiceZyme view of 1.1.1.84

• EC2PDB: PDB structures for 1.1.1.84

• PRIAM entry for 1.1.1.84

• PUMA2 entry for 1.1.1.84

• IntEnz: Integrated Enzyme entry for 1.1.1.84

• MetaCyc entry for 1.1.1.84

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047867: dimethylmalate dehydrogenase

• AMIGO entry for GO code 0047867: dimethylmalate dehydrogenase