Dimethylglycine oxidase

From Wikipedia, the free encyclopedia

In enzymology, a dimethylglycine oxidase (EC 1.5.3.10) is an enzyme that catalyzes the chemical reaction

N,N-dimethylglycine + H₂O + O₂ sarcosine + formaldehyde + H₂O₂

The 3 substrates of this enzyme are N,N-dimethylglycine, H₂O, and O₂, whereas its 3 products are sarcosine, formaldehyde, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N,N-dimethylglycine:oxygen oxidoreductase (demethylating). It employs one cofactor, FAD.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1PJ5, 1PJ6, and 1PJ7.

[edit] References

• IUBMB entry for 1.5.3.10
• BRENDA references for 1.5.3.10 (Recommended.)
• PubMed references for 1.5.3.10
• PubMed Central references for 1.5.3.10
• Google Scholar references for 1.5.3.10
• Mori N, Kawakami B, Tani Y and Yamada H (1980). "Purification and properties of dimethylglycine oxidase from Cylindrocarpon didymum M-1". Agric. Biol. Chem. 44: 1383–1389. 

[edit] External links

The CAS registry number for this enzyme class is 74870-79-4.

• IUBMB entry for 1.5.3.10

• KEGG entry for 1.5.3.10

• BRENDA entry for 1.5.3.10

• NiceZyme view of 1.5.3.10

• EC2PDB: PDB structures for 1.5.3.10

• PRIAM entry for 1.5.3.10

• PUMA2 entry for 1.5.3.10

• IntEnz: Integrated Enzyme entry for 1.5.3.10

• MetaCyc entry for 1.5.3.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047866: dimethylglycine oxidase

• AMIGO entry for GO code 0047866: dimethylglycine oxidase