Dimethylglycine dehydrogenase

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In enzymology, a dimethylglycine dehydrogenase (EC 1.5.99.2) is an enzyme that catalyzes the chemical reaction

N,N-dimethylglycine + acceptor + H₂O $\rightleftharpoons$ sarcosine + formaldehyde + reduced acceptor

The 3 substrates of this enzyme are N,N-dimethylglycine, acceptor, and H₂O, whereas its 3 products are sarcosine, formaldehyde, and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is N,N-dimethylglycine:acceptor oxidoreductase (demethylating). Other names in common use include N,N-dimethylglycine oxidase, and N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating). This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, FAD.

[edit] References

IUBMB entry for 1.5.99.2
BRENDA references for 1.5.99.2 (Recommended.)
PubMed references for 1.5.99.2
PubMed Central references for 1.5.99.2
Google Scholar references for 1.5.99.2
FRISELL WR, MACKENZIE CG (1962). "Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase". J. Biol. Chem. 237: 94–8. PMID 13895406.
HOSKINS DD, MACKENZIE CG (1961). "Solubilization and electron transfer flavoprtein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase". J. Biol. Chem. 236: 177–83. PMID 13716069.