Dimethyl pimelimidate dihydrochloride

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Dimethyl pimelimidate dihydrochloride


IUPAC name	1,7-dimethoxyheptane-1,7-diimine dihydrochloride
Other names	Pimelimidic acid dimethyl ester dihydrochloride, dimethyl heptane-1,7-diimidate dihydrochloride
Identifiers
CAS number	[58537-94-3]
PubChem	11402688
SMILES	COC(=N)CCCCCC(=N)OC.Cl.Cl
Properties
Molecular formula	[CH₃OC(=NH)CH₂CH₂]₂CH₂ · 2HCl
Molar mass	259.17 g/mol
Appearance	white crystalline powder
Melting point	122 °C
Solubility in water	Slightly soluble
Hazards
NFPA 704	1 1 0
Flash point	Not determined
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Dimethyl pimelimidate dihydrochloride (IUPAC systematic name: 1,7-dimethoxyheptane-1,7-diimine dihydrochloride) (often abbreviated as DMP), is an organic chemical compound with two functional imine groups, which both bind to free amino groups at pH range 7.0-10.0 to form amidine bonds.

[edit] Uses

DMP is used mainly as bifunctional coupling reagent to link proteins. It is often used to prepare antibody affinity columns. The appropriate antibody is first incubated with Protein A or Protein G-agarose and allowed to bind. DMP is then added to couple the molecules together.

[edit] Health effects

Dimethyl pimelimidate (DMP) is irritating to the eyes, skin, mucous membranes and upper respiratory tract. It can exert harmful effects by inhalation, ingestion, or skin absorption.