Dihydroxyphenylalanine ammonia-lyase

From Wikipedia, the free encyclopedia

In enzymology, a dihydroxyphenylalanine ammonia-lyase (EC 4.3.1.11) is an enzyme that catalyzes the chemical reaction

3,4-dihydroxy-L-phenylalanine trans-caffeate + NH₃

Hence, this enzyme has one substrate, 3,4-dihydroxy-L-phenylalanine, and two products, trans-caffeate and NH₃.

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is 3,4-dihydroxy-L-phenylalanine ammonia-lyase (trans-caffeate-forming). Other names in common use include beta-(3,4-dihydroxyphenyl)-L-alanine (DOPA) ammonia-lyase, and 3,4-dihydroxy-L-phenylalanine ammonia-lyase. This enzyme participates in tyrosine metabolism.

[edit] References

• IUBMB entry for 4.3.1.11
• BRENDA references for 4.3.1.11 (Recommended.)
• PubMed references for 4.3.1.11
• PubMed Central references for 4.3.1.11
• Google Scholar references for 4.3.1.11
• MacLeod NJ and Pridham JB (1963). "Deamination of beta-(3,4-dihydroxyphenyl)-L-alanine by plants". Biochem. J. 88: 45. 

[edit] External links

The CAS registry number for this enzyme class is 37290-92-9.

• IUBMB entry for 4.3.1.11

• KEGG entry for 4.3.1.11

• BRENDA entry for 4.3.1.11

• NiceZyme view of 4.3.1.11

• EC2PDB: PDB structures for 4.3.1.11

• PRIAM entry for 4.3.1.11

• PUMA2 entry for 4.3.1.11

• IntEnz: Integrated Enzyme entry for 4.3.1.11

• MetaCyc entry for 4.3.1.11

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047859: dihydroxyphenylalanine ammonia-lyase

• AMIGO entry for GO code 0047859: dihydroxyphenylalanine ammonia-lyase