Dihydrouracil dehydrogenase (NAD+)

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In enzymology, a dihydrouracil dehydrogenase (NAD+) (EC 1.3.1.1) is an enzyme that catalyzes the chemical reaction

5,6-dihydrouracil + NAD⁺ uracil + NADH + H⁺

Thus, the two substrates of this enzyme are 5,6-dihydrouracil and NAD⁺, whereas its 3 products are uracil, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6-dihydrouracil:NAD+ oxidoreductase. Other names in common use include dehydrogenase, dihydrouracil, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, pyrimidine reductase, thymine reductase, uracil reductase, and dihydrouracil dehydrogenase (NAD+). This enzyme participates in 3 metabolic pathways: pyrimidine metabolism, beta-alanine metabolism, and pantothenate and coa biosynthesis.

[edit] References

• IUBMB entry for 1.3.1.1
• BRENDA references for 1.3.1.1 (Recommended.)
• PubMed references for 1.3.1.1
• PubMed Central references for 1.3.1.1
• Google Scholar references for 1.3.1.1
• CAMPBELL LL Jr (1957). "Reductive degradation of pyrimidines. III. Purification and properties of dihydrouracil dehydrogenase". J. Biol. Chem. 227: 693–700. PMID 13462991. 

[edit] External links

The CAS registry number for this enzyme class is 9026-89-5.

• IUBMB entry for 1.3.1.1

• KEGG entry for 1.3.1.1

• BRENDA entry for 1.3.1.1

• NiceZyme view of 1.3.1.1

• EC2PDB: PDB structures for 1.3.1.1

• PRIAM entry for 1.3.1.1

• PUMA2 entry for 1.3.1.1

• IntEnz: Integrated Enzyme entry for 1.3.1.1

• MetaCyc entry for 1.3.1.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004159: dihydrouracil dehydrogenase (NAD+)

• AMIGO entry for GO code 0004159: dihydrouracil dehydrogenase (NAD+)