Dihydrosanguinarine 10-monooxygenase
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In enzymology, a dihydrosanguinarine 10-monooxygenase (EC 1.14.13.56) is an enzyme that catalyzes the chemical reaction
- dihydrosanguinarine + NADPH + H+ + O2
10-hydroxydihydrosanguinarine + NADP+ + H2O
The 4 substrates of this enzyme are dihydrosanguinarine, NADPH, H+, and O2, whereas its 3 products are 10-hydroxydihydrosanguinarine, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating). This enzyme is also called dihydrosanguinarine 10-hydroxylase. This enzyme participates in alkaloid biosynthesis i.
[edit] References
- IUBMB entry for 1.14.13.56
- BRENDA references for 1.14.13.56 (Recommended.)
- PubMed references for 1.14.13.56
- PubMed Central references for 1.14.13.56
- Google Scholar references for 1.14.13.56
- De-Eknamkul W, Tanahashi T and Zenk MH (1992). "Enzymic 10-hydroxylation and 10-O-methylation of dihydrosanguinarine in dihydrochelirubine formation by Eschscholtzia". Phytochemistry 31: 2713–2717. doi:.
[edit] External links
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- The CAS registry number for this enzyme class is 144388-41-0.
[edit] Gene Ontology (GO) codes
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