Dihydroneopterin aldolase

From Wikipedia, the free encyclopedia

In enzymology, a dihydroneopterin aldolase (EC 4.1.2.25) is an enzyme that catalyzes the chemical reaction

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- dihydropteridine 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde

Thus, the two substrates of this enzyme are 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- and dihydropteridine, whereas its two products are 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and glycolaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropt eridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming). Other names in common use include 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-, and dihydropteridine glycolaldehyde-lyase. This enzyme participates in folate biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1NBU, 1RRI, 1RRW, 1RRY, 1RS2, 1RS4, 1RSD, 1RSI, 1U68, 1Z9W, 2CG8, 2NM2, and 2NM3.

[edit] References

• IUBMB entry for 4.1.2.25
• BRENDA references for 4.1.2.25 (Recommended.)
• PubMed references for 4.1.2.25
• PubMed Central references for 4.1.2.25
• Google Scholar references for 4.1.2.25
• Mathis JB, Brown GM (1970). "The biosynthesis of folic acid. XI. Purification and properties of dihydroneopterin aldolase". J. Biol. Chem. 245: 3015–25. PMID 4912541. 

[edit] External links

The CAS registry number for this enzyme class is 37290-59-8.

• IUBMB entry for 4.1.2.25

• KEGG entry for 4.1.2.25

• BRENDA entry for 4.1.2.25

• NiceZyme view of 4.1.2.25

• EC2PDB: PDB structures for 4.1.2.25

• PRIAM entry for 4.1.2.25

• PUMA2 entry for 4.1.2.25

• IntEnz: Integrated Enzyme entry for 4.1.2.25

• MetaCyc entry for 4.1.2.25

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004150: dihydroneopterin aldolase

• AMIGO entry for GO code 0004150: dihydroneopterin aldolase