Dihydrokaempferol 4-reductase

From Wikipedia, the free encyclopedia

In enzymology, a dihydrokaempferol 4-reductase (EC 1.1.1.219) is an enzyme that catalyzes the chemical reaction

cis-3,4-leucopelargonidin + NADP⁺ $\rightleftharpoons$ (+)-dihydrokaempferol + NADPH + H⁺

Thus, the two substrates of this enzyme are cis-3,4-leucopelargonidin and NADP⁺, whereas its 3 products are (+)-dihydrokaempferol, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase. Other names in common use include dihydroflavanol 4-reductase, dihydromyricetin reductase, NADPH-dihydromyricetin reductase, and dihydroquercetin reductase. This enzyme participates in flavonoid biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2C29 and 2IOD.

[edit] References

IUBMB entry for 1.1.1.219
BRENDA references for 1.1.1.219 (Recommended.)
PubMed references for 1.1.1.219
PubMed Central references for 1.1.1.219
Google Scholar references for 1.1.1.219
Heller W, Forkmann G, Britsch L and Grisebach H (1985). "Enzymatic reduction of (+)-dihydroflavonols to flavan-3,4-cis- diols with flower extracts from Matthiola incana and its role in anthocyanin biosynthesis". Planta 165: 284–287. doi:10.1007/BF00395052.
Stafford HA and Lester HH (1985). "Flavan-3-ol biosynthesis the conversion of (+)- dihydromyricetin to its flavan-3,4-diol (leucodelphinidin) and to (+)-gallocatechin by reductases extracted from tissue-cultures of Ginkgo biloba and Pseudotsuga-menziesii". Plant Physiol. 78: 791–794.