Dihydrobunolol dehydrogenase

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In enzymology, a dihydrobunolol dehydrogenase (EC 1.1.1.160) is an enzyme that catalyzes the chemical reaction

(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1- naphthol + NADP⁺ $\rightleftharpoons$ (+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)- naphthalenone + NADPH + H⁺

The three substrates of this enzyme are [[(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-]], naphthol, and NADP⁺, whereas its 4 products are [[(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-]], naphthalenone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-n aphthol:NADP+ oxidoreductase. This enzyme is also termed bunolol reductase.

[edit] References

IUBMB entry for 1.1.1.160
BRENDA references for 1.1.1.160 (Recommended.)
PubMed references for 1.1.1.160
PubMed Central references for 1.1.1.160
Google Scholar references for 1.1.1.160
Leinweber FJ, Greenough RC, Schwender CF, Kaplan HR, Di Carlo FJ (1972). "Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol". Xenobiotica. 2: 191–202. PMID 4560367.
Leinweber FJ, Greenough RC, Schwender CF, Kaplan HR, Di Carlo FJ (1972). "Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol". Xenobiotica. 2: 191–202. PMID 4560367.