Dihydrobenzophenanthridine oxidase

From Wikipedia, the free encyclopedia

Dihydrobenzophenanthridine oxidase (DHBP oxidase) is an enzyme. In the IUBMB Enzyme Nomenclature, Dihydrobenzophenanthridine oxidase is EC 1.5.3.12. Dihydrobenzophenanthridine oxidase/EC 1.5.3.12 produces oxidized forms of benzophenanthridine alkaloids:

• In Sanguinaria Canadensis EC 1.5.3.12 produces sanguinarine from dihydrosanguinarine, and chelirubine from dihydrochelirubine.
• In California poppy, EC 1.5.3.12 produces macarpine from dihydromacarpine.

[edit] External links

• EC 1.5.3.12 International Union of Biochemistry and Molecular Biology, Recommendations on Biochemical & Organic Nomenclature, Symbols & Terminology etc., web interface.

• Chelirubine, Macarpine, and Sanguinarine Biosynthesis ibid.

• Ignatov A, Clark WG, Cline SD, Psenak M, Krueger J, Coscia CJ (1996). "Elicitation of dihydrobenzophenanthridine oxidase in Sanguinaria canadensis cell cultures". Phytochemistry 43 (6): 1141–4. doi:10.1016/S0031-9422(96)00540-7. PMID 8987906. 

• Park SU, Yu M, Facchini PJ (2002). "Antisense RNA-mediated suppression of benzophenanthridine alkaloid biosynthesis in transgenic cell cultures of California poppy". Plant Physiol. 128 (2): 696–706. doi:10.1104/pp.010741. PMID 11842172. 

• Rho D, Chauret N, Laberge N, Archambault J (1992). "Growth characteristics of Sanguinaria canadensis L. cell suspensions and immobilized cultures for production of benzophenanthridine alkaloids". Appl. Microbiol. Biotechnol. 36 (5): 611–7. PMID 1368065. 

• KEGG (Kyoto Encyclopedia of Genes and Genomes) Alkaloid biosynthesis I - Reference pathway

v • d • e CH-NH oxidoreductases (EC 1.5) 1.5.1 - NAD or NADP acceptor Dihydrofolate reductase - Saccharopine dehydrogenase - Methylenetetrahydrofolate reductase 1.5.3 - oxygen acceptor Dihydrobenzophenanthridine oxidase - Sarcosine oxidase - Proline oxidase 1.5.5 - quinone acceptor Electron-transferring-flavoprotein dehydrogenase