Diglyceride acyltransferase
From Wikipedia, the free encyclopedia
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diacylglycerol O-acyltransferase homolog 1 (mouse)
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| Identifiers | |
| Symbol | DGAT1 |
| Entrez | 8694 |
| HUGO | 2843 |
| OMIM | 604900 |
| RefSeq | NM_012079 |
| UniProt | O75907 |
| Other data | |
| EC number | 2.3.1.20 |
| Locus | Chr. 8 q24.3 |
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diacylglycerol O-acyltransferase homolog 2 (mouse)
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| Identifiers | |
| Symbol | DGAT2 |
| Entrez | 84649 |
| HUGO | 16940 |
| OMIM | 606983 |
| RefSeq | NM_032564 |
| UniProt | Q96PD7 |
| Other data | |
| Locus | Chr. 11 q13.3 |
Diglyceride acyltransferase (or O-acyltransferase), DGAT, catalyzes the formation of triglycerides from diacylglycerol and Acyl-CoA. There are two isoforms of DGAT encoded by the genes DGAT1 and DGAT2. DGAT is considered the terminal and only committed step in triglyceride synthesis and to be essential for the formation of adipose tissue.[1] A number of pharmaceutical companies currently have DGAT-1 inhibitors in clinical trials for the treatment of obesity.[2]
[edit] References
- ^ Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV (1998). "Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13018–23. PMID 9789033.
- ^ Pfizer, Bristol finalize deal on metabolic drugs. Retrieved on 2007-08-27.
