Diferric-transferrin reductase

From Wikipedia, the free encyclopedia

In enzymology, a diferric-transferrin reductase (EC 1.16.1.2) is an enzyme that catalyzes the chemical reaction

transferrin[Fe(II)]2 + NAD⁺ + H⁺ transferrin[Fe(III)]2 + NADH

The 3 substrates of this enzyme are [[transferrin[Fe(II)]2]], NAD⁺, and H⁺, whereas its two products are [[transferrin[Fe(III)]2]] and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is transferrin[Fe(II)]2:NAD+ oxidoreductase. Other names in common use include diferric transferrin reductase, NADH diferric transferrin reductase, and transferrin reductase. This enzyme participates in porphyrin and chlorophyll metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1L5T.

[edit] References

• IUBMB entry for 1.16.1.2
• BRENDA references for 1.16.1.2 (Recommended.)
• PubMed references for 1.16.1.2
• PubMed Central references for 1.16.1.2
• Google Scholar references for 1.16.1.2
• Low H, Sun IL, Navas P, Grebing C, Crane FL, Morre DJ (1986). "Transplasmalemma electron transport from cells is part of a diferric transferrin reductase system". Biochem. Biophys. Res. Commun. 139: 1117–23. doi:10.1016/S0006-291X(86)80293-5. PMID 3767994. 

[edit] External links

The CAS registry number for this enzyme class is 105238-49-1.

• IUBMB entry for 1.16.1.2

• KEGG entry for 1.16.1.2

• BRENDA entry for 1.16.1.2

• NiceZyme view of 1.16.1.2

• EC2PDB: PDB structures for 1.16.1.2

• PRIAM entry for 1.16.1.2

• PUMA2 entry for 1.16.1.2

• IntEnz: Integrated Enzyme entry for 1.16.1.2

• MetaCyc entry for 1.16.1.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047852: diferric-transferrin reductase

• AMIGO entry for GO code 0047852: diferric-transferrin reductase