Diethyltryptamine

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Diethyltryptamine
Systematic (IUPAC) name
N,N-diethyl-2-(1H-indol-3-yl)ethanamine
Identifiers
CAS number 7558-72-7
ATC code  ?
PubChem 6090
Chemical data
Formula C14H20N2 
Mol. mass 216.32 g/mol
SMILES eMolecules & PubChem
Physical data
Melt. point 169–171 °C (336–340 °F)
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status

Class A(UK) Schedule I(US)
Routes  ?

DET (N,N-diethyltryptamine) or T-9 [1] is a psychedelic drug closely related to DMT and 4-HO-DET. However, despite its structural similarity to DMT it is active orally around 50–100mg without the aid of MAO inhibitors lasting about 2-4 hours.

Contents

[edit] Pharmacology

The mechanism of action is thought to be serotonin receptor agonism, much like other classic psychedelics.[2]

[edit] Biochemistry

Though DET is a synthetic compound with no known natural sources it has been used with mycelium of Psilocybe cubensis to produce the synthetic chemicals 4-PO-DET and 4-HO-DET, as opposed the naturally occurring 4-PO-DMT (Psilocybin) and 4-HO-DMT (Psilocin). Isolation of the alkaloids resulted in 3.3% 4-HO-DET and 0.01-0.8% 4-PO-DET.[3]

[edit] Psychosis model

Early studies of DET, as well as other psychedelics, mainly focused on the believed psychotomimetic properties.[4] Researchers theorized that abnormal metabolites of endogenous chemicals such as tryptamine, serotonin, and tryptophan could be the explanation for mental disorders as schizophrenia, or psychosis.[5] With the progression of science and pharmacological understanding this belief remains dismissed by most researchers.

[edit] See also

[edit] References

  1. ^ Erowid DET Vault : Chemistry. Retrieved on 2008-01-08.
  2. ^ BEHAVIORAL EFFECTS OF N, N-DIETHYLTRYPTAMINE: ABSENCE OF ANTAGONISM BY XYLAMIDINE TOSYLATE -- WINTER 169 (1): 7 -- Journal of Pharmacology And Experimental Therapeutics. Retrieved on 2008-01-03.
  3. ^ Biotransformation of tryptamine derivatives in myc...[J Basic Microbiol. 1989 - PubMed Result]. Retrieved on 2008-01-03.
  4. ^ [http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2633 PSILOCYBIN AND DIETHYLTRYPTAMINE: TWO TRYPTAMINE HALLUCINOGENS]. Retrieved on 2008-01-03.
  5. ^ Effects of LSD-25, N,N-Dimethyltryptamine (DMT), and N,N-Diethyltryptamine (DET) on the Photic Evoked Responses in the unanesthetized Rabbit. Retrieved on 2008-01-03.

[edit] External links

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Psychedelic tryptamines

α,N,N-TMT • 2,N,N-TMT • 5,N,N-TMT • 4-Acetoxy-DMT • 4-Acetoxy-DET • 4-Acetoxy-DIPT • 4-HO-5-MeO-DMT • α-ET • α-MT • Baeocystin • Bufotenin • DBT • DET • DIPT • DMT • DPT • EiPT • PiPT • Ethocin • Ethocybin • Iprocin • 4-HO-MET • 4-HO-MiPT • MET • MIPT • 5-Me-MIPT • 5-MeO-α-ET • 5-MeO-α-MT • 5-MeO-DALT • 5-MeO-DET • 5-MeO-DIPT • 5-MeO-DMT • 5-MeO-DPT • 5-MeO-MET • 5-MeO-MIPT • 5-MeO-α,N,N-TMT • 5-MeO-2,N,N-TMT • Miprocin • Norbaeocystin • Psilocin • Psilocybin
v • d • e
Drugs from TiHKAL
v • d • e
Tryptamines

4-Acetoxy-DET • 4-Acetoxy-DIPT • 4-Acetoxy-DMT • 4-HO-DIPT • 5-Bromo-DMT • 5-Fluoro-α-MT • 5-MeO-α-ET  • 5-MeO-α-MT • 5-MeO-DALT • 5-MeO-DET • 5-MeO-DIPT • 5-MeO-DMT • 5-MeO-DPT • 5-MeO-MIPT • α-ET • α-MT • Aeruginascin • Baeocystin • Bufotenin • DET • DiPT • DMT • DPT • Ethocybin • EiPT • Ethocin • Ibogaine • Iprocin • MET • MiPT • Miprocin • Melatonin • NMT • Norbaeocystin • Normelatonin • PiPT • Psilocin • Psilocybin • Rizatriptan • Serotonin • Sumatriptan • Tryptamine • Tryptophan