Dicarboxylate-CoA ligase

From Wikipedia, the free encyclopedia

In enzymology, a dicarboxylate-CoA ligase (EC 6.2.1.23) is an enzyme that catalyzes the chemical reaction

ATP + an alphaomega-dicarboxylic acid + CoA AMP + diphosphate + an omega-carboxyacyl-CoA

The 3 substrates of this enzyme are ATP, alphaomega-dicarboxylic acid, and CoA, whereas its 3 products are AMP, diphosphate, and omega-carboxyacyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is omega-dicarboxylate:CoA ligase (AMP-forming). Other names in common use include carboxylyl-CoA synthetase, and dicarboxylyl-CoA synthetase.

[edit] References

• IUBMB entry for 6.2.1.23
• BRENDA references for 6.2.1.23 (Recommended.)
• PubMed references for 6.2.1.23
• PubMed Central references for 6.2.1.23
• Google Scholar references for 6.2.1.23
• Vamecq J, de Hoffmann E, Van Hoof F (1985). "The microsomal dicarboxylyl-CoA synthetase". Biochem. J. 230: 683–93. PMID 4062873. 

[edit] External links

The CAS registry number for this enzyme class is 99332-77-1.

• IUBMB entry for 6.2.1.23

• KEGG entry for 6.2.1.23

• BRENDA entry for 6.2.1.23

• NiceZyme view of 6.2.1.23

• EC2PDB: PDB structures for 6.2.1.23

• PRIAM entry for 6.2.1.23

• PUMA2 entry for 6.2.1.23

• IntEnz: Integrated Enzyme entry for 6.2.1.23

• MetaCyc entry for 6.2.1.23

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047851: dicarboxylate-CoA ligase

• AMIGO entry for GO code 0047851: dicarboxylate-CoA ligase